INT120467

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)
LCT (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 76.16 Quite High
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lactose Intolerance 2 83.64 Quite High
Genetic Predisposition To Disease 2 78.40 Quite High
Malabsorption Syndromes 10 77.52 Quite High
Abdominal Pain 2 76.16 Quite High
Flatulence 2 75.36 Quite High
Diarrhoea 2 74.44 Quite High
Microcephaly 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hereditary persistence of lactase is common primarily in people of northern European descent and is attributed to inheritance of an autosomal-dominant mutation that prevents the maturational decline in lactase expression.
Negative_regulation (prevents) of Gene_expression (expression) of lactase
1) Confidence 0.59 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.67 Pain Relevance 0.08
This hereditary persistence of lactase is common primarily in people of northern European descent and is attributed to inheritance of an autosomal-dominant mutation that prevents the maturational decline in lactase expression.
Negative_regulation (decline) of Gene_expression (expression) of lactase
2) Confidence 0.43 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15287817 Disease Relevance 0.67 Pain Relevance 0.08
There are all reasons to believe that Neanderthals carried the ancestral allele, namely a C/T substitution at position -13910 with respect to the modern allele causing persistence of lactase enzyme production after waning, and thus of the ability to digest milk.
Negative_regulation (persistence) of Gene_expression (production) of lactase
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0

General Comments

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