INT120471

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (STMN1) signal transduction (STMN1) cytoskeleton (STMN1)
intracellular (STMN1) cytoplasm (STMN1) signal transducer activity (STMN1)
Anatomy Link Frequency
NAc 1
neurons 1
STMN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 3 100.00 Very High Very High Very High
cocaine 3 99.32 Very High Very High Very High
Kinase C 65 99.16 Very High Very High Very High
Morphine 10 97.24 Very High Very High Very High
Nucleus accumbens 3 94.88 High High
Inflammation 9 90.04 High High
opioid receptor 1 69.60 Quite High
Central nervous system 10 25.00 Low Low
nMDA receptor 2 25.00 Low Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 89 100.00 Very High Very High Very High
Infection 29 96.80 Very High Very High Very High
Borna Disease 4 93.68 High High
INFLAMMATION 8 90.04 High High
Neurological Disease 4 87.64 High High
Disease 7 82.88 Quite High
Apoptosis 8 45.20 Quite Low
Dermatomyositis 9 5.00 Very Low Very Low Very Low
Rheumatic Diseases 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results confirmed that SRP72 was a phosphoprotein to which a serine residue is phosphorylated (25).
Phosphorylation (phosphorylated) of phosphoprotein
1) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.17 Pain Relevance 0.09
Using genetically engineered recombinant viruses, we show that the phosphorylation of BDV phosphoprotein (P) by the cellular protein kinase C (PKC) is the main determinant for this interference, mainly by competing with the phosphorylation of the natural PKC substrates in neurons.
Phosphorylation (phosphorylation) of phosphoprotein in neurons associated with virus diseases and kinase c
2) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.80 Pain Relevance 0.29
Cocaine-sensitized rats showed increased phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein Mr 32 kDa (DARPP-32) at threonine-75 (Thr75) and decreased DARPP-32 phosphorylation at Thr34, in the caudate-putamen (CPu) and nucleus accumbens (NAc) 7 days after sensitization assessment.
Phosphorylation (phosphorylation) of phosphoprotein in NAc associated with nucleus accumbens, dopamine and cocaine
3) Confidence 0.00 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 0.83

General Comments

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