INT120483

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 12.05
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
macrophages 2
microglia 2
spinal 1
striatum 1
urine 1
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 1 99.84 Very High Very High Very High
Hippocampus 22 96.96 Very High Very High Very High
Pain 7 96.96 Very High Very High Very High
Inflammatory response 22 94.76 High High
antagonist 40 94.40 High High
chemokine 125 94.08 High High
Spinal cord 1 93.32 High High
cytokine 39 92.16 High High
cocaine 86 89.32 High High
dexamethasone 4 88.16 High High
Disease Link Frequency Relevance Heat
Stress 90 99.98 Very High Very High Very High
Dementia 93 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 633 99.16 Very High Very High Very High
Toxicity 100 98.96 Very High Very High Very High
Infection 186 98.66 Very High Very High Very High
Pain 5 96.96 Very High Very High Very High
Ovarian Cancer 29 96.88 Very High Very High Very High
Hepatitis C Virus Infection 189 96.72 Very High Very High Very High
Neurodegenerative Disease 122 95.04 Very High Very High Very High
Viral Meningitis 14 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Localization (excretion) of ITIH4 in urine associated with ovarian cancer
1) Confidence 0.69 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.51 Pain Relevance 0
We have shown that estradiol reduces the oxidative stress elicited by gp120 and Tat in SK-N-SH cells and
Localization (elicited) of gp120 in SK-N-SH associated with stress
2) Confidence 0.52 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.13 Pain Relevance 0.41
Once released, Tat and gp120 have been shown to exert toxicity through an oxidative stress pathway [4–6, 75].
Localization (released) of gp120 associated with stress and toxicity
3) Confidence 0.49 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.52 Pain Relevance 0.14
In this regards, it is interesting that in a rat model gp120 is transported into cortical neurons by retrograde axonal transport from the striatum and hippocampus [34].



Localization (transported) of gp120 in hippocampus associated with hippocampus
4) Confidence 0.22 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.77 Pain Relevance 0.17
HIV-1 exerts its direct neurotoxic effects through several secreted proteins including gp120, Tat, Nef and Vpr [14].
Localization (secreted) of gp120 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.98 Pain Relevance 0.19
One model used to study this is peri-spinal (intrathecal, i.t.) administration of gp120, an envelope protein of HIV-1 known to activate glia.
Localization (administration) of gp120 in spinal associated with acquired immune deficiency syndrome or hiv infection and intrathecal
6) Confidence 0.14 Published 2004 Journal Pain Section Abstract Doc Link 15288392 Disease Relevance 0.64 Pain Relevance 0.58
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (release) of gp120 in microglia associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
7) Confidence 0.10 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.22 Pain Relevance 0.21
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (released) of gp120 in microglia associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
8) Confidence 0.08 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.14 Pain Relevance 0.21
In this regards, it is interesting that in a rat model gp120 is transported into cortical neurons by retrograde axonal transport from the striatum and hippocampus [34].



Localization (transported) of gp120 in striatum associated with hippocampus
9) Confidence 0.07 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.77 Pain Relevance 0.17
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (release) of gp120 in macrophages associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
10) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.22 Pain Relevance 0.21
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (released) of gp120 in macrophages associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
11) Confidence 0.03 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.14 Pain Relevance 0.21

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