INT120509

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 65
Total Number 89
Disease Relevance 50.90
Pain Relevance 9.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
lungs 11
liver 4
cardiac myocytes 3
macrophages 2
skeletal muscle 2
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1256 99.84 Very High Very High Very High
fibrosis 1298 99.48 Very High Very High Very High
Arthritis 124 98.40 Very High Very High Very High
agonist 71 97.12 Very High Very High Very High
acular 27 96.68 Very High Very High Very High
Demyelination 130 96.26 Very High Very High Very High
ischemia 63 94.24 High High
Paracetamol 14 93.36 High High
tolerance 72 90.32 High High
Potency 14 90.20 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 237 99.98 Very High Very High Very High
Mycobacterial Infection 145 99.98 Very High Very High Very High
Death 136 99.92 Very High Very High Very High
Sprains And Strains 276 99.88 Very High Very High Very High
Infection 140 99.88 Very High Very High Very High
INFLAMMATION 1196 99.84 Very High Very High Very High
Fibrosis 1020 99.84 Very High Very High Very High
Stress 783 99.66 Very High Very High Very High
Pulmonary Fibrosis 668 99.48 Very High Very High Very High
Diabetes Mellitus 284 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, bronchiolar epithelial cells in fibrotic lungs showed decreased catalase expression to various degrees (Figure 2B).
Gene_expression (expression) of catalase in epithelial cells associated with fibrosis
1) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.56 Pain Relevance 0
In the lungs, catalase is expressed during the later stages of development, is constitutively expressed in airway and alveolar epithelial cells and in macrophages [10-12], and plays an important role in the endogenous antioxidant defense system.
Gene_expression (expressed) of catalase in macrophages
2) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.92 Pain Relevance 0.15
For example, treatment with a catalase/superoxide dismutase mimetic, or adenoviral-mediated overexpression of catalase, inhibits hydrogen peroxide-stimulated EMMPRIN upregulation in cardiac myocytes [38].
Gene_expression (overexpression) of catalase in cardiac myocytes
3) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.59 Pain Relevance 0.26
The significance of catalase mRNA expression among the groups persisted at 7 and 14 days when normalized by BGUS (p < 0.05, respectively).
Gene_expression (expression) of catalase mRNA
4) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.36 Pain Relevance 0.15
The significance of catalase mRNA expression between the two groups persisted when normalized by 18s rRNA (0.62 ± 0.1 vs. 1.6 ± 0.1, p = 0.0002).
Gene_expression (expression) of catalase mRNA
5) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.70 Pain Relevance 0.07
Further to this idea, in one study a transgenic mouse overexpressing catalase localized to mitochondria showed an extended life span due to enhanced protection of mitochondria from reactive oxygen species (ROS), in which catalase overexpression also suppressed age-related DNA oxidation in skeletal muscle [7].
Gene_expression (overexpression) of catalase in skeletal muscle associated with targeted disruption
6) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.71 Pain Relevance 0.15
Catalase mRNA was present in bronchiolar epithelial cells, and the expression levels were significantly lower at 7 days after bleomycin administration compared with untreated lungs (p = 0.009) (Figure 3C).


Gene_expression (present) of Catalase mRNA in lungs
7) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.23 Pain Relevance 0.07
In the lungs, catalase is expressed during the later stages of development, is constitutively expressed in airway and alveolar epithelial cells and in macrophages [10-12], and plays an important role in the endogenous antioxidant defense system.
Gene_expression (expressed) of catalase in macrophages
8) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.84 Pain Relevance 0.12
To assess whether the reduction in catalase activity in fibrotic lungs is due to the decreased synthesis of catalase, we quantified catalase expression in lung tissues using Western blotting and quantitative RT-PCR.
Gene_expression (expression) of catalase in lung associated with fibrosis
9) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.58 Pain Relevance 0.08
Using LCM we harvested bronchiolar epithelial cells from lungs in order to quantify catalase mRNA expression in vivo, as previously described [18].
Gene_expression (expression) of catalase mRNA in lungs
10) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.23 Pain Relevance 0.07
We then examined the dynamic change in bronchiolar catalase expression following administration of bleomycin in mice.
Gene_expression (expression) of catalase
11) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.23 Pain Relevance 0.07
To assess whether the reduction in catalase activity in fibrotic lungs is due to the decreased synthesis of catalase, we quantified catalase expression in lung tissues using Western blotting and quantitative RT-PCR.
Gene_expression (synthesis) of catalase in lung associated with fibrosis
12) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.58 Pain Relevance 0.09
We observed that catalase is predominantly expressed in bronchiolar epithelium in normal lungs, and is diminished in IP lungs, especially in bronchiolar epithelium and in abnormal re-epithelialization, such as bronchiolization and squamous metaplasia in humans (Figure 2).
Gene_expression (expressed) of catalase in lungs associated with metaplasia
13) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.37 Pain Relevance 0.14
To evaluate the effects of Lb. casei BL23 producing or not MnKat catalase on inflammation development, two groups of mice received 5 × 109 cfu/mouse of either Lb. casei MnKat- or Lb. casei MnKat+ by intragastric administration one day before starting DSS administration and then daily until sacrifice.
Gene_expression (producing) of MnKat catalase associated with inflammation
14) Confidence 0.70 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.75 Pain Relevance 0.15
Glutathione-S-transferase-Pi and catalase were overexpressed in the lungs of mice exposed to light only.
Gene_expression (overexpressed) of catalase in lungs
15) Confidence 0.69 Published 2004 Journal FASEB J. Section Abstract Doc Link 15289447 Disease Relevance 0.30 Pain Relevance 0.05
Firstly, we investigated the contribution of brain catalase in the acquisition of ethanol-induced conditioned place preference (CPP).
Spec (investigated) Gene_expression (contribution) of catalase in brain
16) Confidence 0.67 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18155096 Disease Relevance 0.08 Pain Relevance 0.21
METHODS: Swiss male mice received an intraperitoneal injection of the catalase inhibitor 3-amino-1,2,4-triazole (AT; 0-1 g/kg), and 0 to 20 hr after this administration, animals received an ethanol (0-4 g/kg; intraperitoneally) challenge.
Gene_expression (injection) of catalase
17) Confidence 0.67 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608607 Disease Relevance 0 Pain Relevance 0
It also should be noted that fibroblastic foci were exclusively negative for catalase in fibrotic lungs.
Neg (negative) Gene_expression (negative) of catalase in lungs associated with fibrosis
18) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.67 Pain Relevance 0.24
Contamination by red blood cells does not contribute to catalase activity of the lungs
Gene_expression (activity) of catalase in lungs
19) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.49 Pain Relevance 0.03
For example, treatment with a catalase/superoxide dismutase mimetic, or adenoviral-mediated overexpression of catalase, inhibits hydrogen peroxide-stimulated EMMPRIN upregulation in cardiac myocytes [38].
Gene_expression (overexpression) of catalase in cardiac myocytes
20) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.60 Pain Relevance 0.27

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