INT120511

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 31
Disease Relevance 19.82
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
optic nerve 10
cardiac myocytes 6
skin 6
liver 4
skeletal muscle 4
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 124 98.40 Very High Very High Very High
agonist 70 97.64 Very High Very High Very High
acular 27 97.08 Very High Very High Very High
Demyelination 130 96.44 Very High Very High Very High
Inflammation 397 95.12 Very High Very High Very High
ischemia 42 94.24 High High
Potency 9 90.60 High High
tolerance 64 90.32 High High
rheumatoid arthritis 57 87.84 High High
Multiple sclerosis 110 84.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 143 99.98 Very High Very High Very High
Stress 299 99.76 Very High Very High Very High
Diabetes Mellitus 183 99.36 Very High Very High Very High
Ganglion Cysts 16 98.62 Very High Very High Very High
Infection 26 98.46 Very High Very High Very High
Arthritis 128 98.40 Very High Very High Very High
Multiple Sclerosis 401 97.68 Very High Very High Very High
Toxicity 44 97.16 Very High Very High Very High
Pressure And Volume Under Development 100 96.64 Very High Very High Very High
Demyelinating Disease 141 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, treatment with a catalase/superoxide dismutase mimetic, or adenoviral-mediated overexpression of catalase, inhibits hydrogen peroxide-stimulated EMMPRIN upregulation in cardiac myocytes [38].
Positive_regulation (overexpression) of Gene_expression (overexpression) of catalase in cardiac myocytes
1) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.59 Pain Relevance 0.26
Further to this idea, in one study a transgenic mouse overexpressing catalase localized to mitochondria showed an extended life span due to enhanced protection of mitochondria from reactive oxygen species (ROS), in which catalase overexpression also suppressed age-related DNA oxidation in skeletal muscle [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of catalase in skeletal muscle associated with targeted disruption
2) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.71 Pain Relevance 0.15
Glutathione-S-transferase-Pi and catalase were overexpressed in the lungs of mice exposed to light only.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of catalase in lungs
3) Confidence 0.62 Published 2004 Journal FASEB J. Section Abstract Doc Link 15289447 Disease Relevance 0.30 Pain Relevance 0.05
The combined effects of in vivo scavenging of hydrogen peroxide by viral mediated catalase gene transfer and superoxide scavenging suppressed the optic nerve cell count by 27% with mean of 243 cells per 105 ?
Positive_regulation (mediated) of Gene_expression (transfer) of catalase in optic nerve
4) Confidence 0.60 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.60 Pain Relevance 0.17
Further to this idea, in one study a transgenic mouse overexpressing catalase localized to mitochondria showed an extended life span due to enhanced protection of mitochondria from reactive oxygen species (ROS), in which catalase overexpression also suppressed age-related DNA oxidation in skeletal muscle [7].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of catalase in skeletal muscle associated with targeted disruption
5) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.87 Pain Relevance 0.22
Contamination by red blood cells does not contribute to catalase activity of the lungs
Neg (not) Positive_regulation (contribute) of Gene_expression (activity) of catalase in lungs
6) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.50 Pain Relevance 0.03
For example, treatment with a catalase/superoxide dismutase mimetic, or adenoviral-mediated overexpression of catalase, inhibits hydrogen peroxide-stimulated EMMPRIN upregulation in cardiac myocytes [38].
Positive_regulation (overexpression) of Gene_expression (overexpression) of catalase in cardiac myocytes
7) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.60 Pain Relevance 0.27
Animals were sacrificed 24 h after administration of final dose of the extract and NIM, liver tissues were collected, and the activities of SOD and CAT and levels of GSH and lipid peroxidation end-product (as MDA), were determined from the livers of all the experimental animals.
Spec (determined) Positive_regulation (determined) of Gene_expression (levels) of CAT in livers
8) Confidence 0.49 Published 2006 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 17133737 Disease Relevance 0.20 Pain Relevance 0.14
The activities of antioxidant enzymes (CAT and GSH-Px) and GSH level in hepatic, pancreatic and renal tissues also increased significantly (P < 0.05) in BMEE-treated mice, but the activity of SOD was not improved significantly.
Positive_regulation (increased) of Gene_expression (level) of CAT
9) Confidence 0.49 Published 2009 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 19374261 Disease Relevance 0.51 Pain Relevance 0.05
The combined effects of in vivo scavenging of hydrogen peroxide by viral mediated catalase gene transfer and superoxide scavenging suppressed the optic nerve cell count by 27% with mean of 243 cells per 105 ?
Positive_regulation (transfer) of Gene_expression (transfer) of catalase in optic nerve
10) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.60 Pain Relevance 0.17
Transgenic mice overexpressing mitochondrial catalase (MCAT) live 17–21% longer than wildtype mice (Schriner et al. 2005).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of catalase associated with targeted disruption
11) Confidence 0.42 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.77 Pain Relevance 0
Immunobloting showed that retinal ganglion cells infected with rAAV containing the gene for human catalase had increased catalase expression relative to controls infected with AAV-GFP (Figure 1G).


Positive_regulation (increased) of Gene_expression (expression) of catalase in retinal ganglion cells associated with ganglion cysts
12) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.97 Pain Relevance 0.16
The combined effects of in vivo scavenging of hydrogen peroxide by viral mediated catalase gene transfer and superoxide scavenging by germ line increases of ECSOD reduced optic nerve head edema by 34% with a mean optic nerve head area of 29,821 ?
Positive_regulation (mediated) of Gene_expression (transfer) of catalase in optic nerve head associated with pressure and volume under development
13) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 1.01 Pain Relevance 0.15
While the 72% suppressive effect on demyelination achieved here is promising, our next steps are to tackle the pitfalls inherent in dual AAV infection of the retina and optic nerve and to demonstrate a protective effect by AAV mediated transfer of both genes (catalase and SOD), or perhaps even a chimeric SOD [48] on chronic EAE.



Positive_regulation (mediated) of Gene_expression (transfer) of catalase in optic nerve associated with multiple sclerosis, demyelination and infection
14) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.93 Pain Relevance 0.36
While the 72% suppressive effect on demyelination achieved here is promising, our next steps are to tackle the pitfalls inherent in dual AAV infection of the retina and optic nerve and to demonstrate a protective effect by AAV mediated transfer of both genes (catalase and SOD), or perhaps even a chimeric SOD [48] on chronic EAE.



Positive_regulation (transfer) of Gene_expression (transfer) of catalase in optic nerve associated with multiple sclerosis, demyelination and infection
15) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.92 Pain Relevance 0.36
In the present study a statistically significant increase in the levels of GSH, SOD, catalase and GPx in the diabetic treated mice with AuNPs in comparison to diabetic control is being proved which is due to the significant decrease in lipid peroxidation and ROS generation that was accomplished in diabetic treated mice with AuNPs, relative to diabetic control suggesting that AuNPs prevents disruption of organs by protecting lipids from peroxidation by ROS under hyperglycemic conditions.
Positive_regulation (increase) of Gene_expression (levels) of catalase associated with diabetes mellitus
16) Confidence 0.27 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.79 Pain Relevance 0.06
After three weeks on the diets, there was a significant increase in the expression levels of SOD and catalase, in addition to the increases in SOD activities.
Positive_regulation (increase) of Gene_expression (expression) of catalase
17) Confidence 0.22 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2668769 Disease Relevance 0.84 Pain Relevance 0.03
In order to determine whether the Protandim diet could induce SOD expression/activity and catalase expression in skin epidermal tissues within a short period of time, animals were fed with either of the two diets for three weeks.
Positive_regulation (induce) of Gene_expression (expression) of catalase in skin
18) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.09 Pain Relevance 0
overexpress human catalase localized to peroxisomes, nuclei, and
Positive_regulation (overexpress) of Gene_expression (overexpress) of catalase
19) Confidence 0.16 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.60 Pain Relevance 0
In order to determine whether the Protandim diet could induce SOD expression/activity and catalase expression in skin epidermal tissues within a short period of time, animals were fed with either of the two diets for three weeks.
Positive_regulation (induce) of Gene_expression (expression) of catalase in skin
20) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.09 Pain Relevance 0

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