INT120521

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.12
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
Spontaneous pain 12 96.16 Very High Very High Very High
Pain 133 95.84 Very High Very High Very High
Neuropathic pain 40 86.28 High High
Eae 52 82.00 Quite High
hyperexcitability 10 78.64 Quite High
tetrodotoxin 2 75.28 Quite High
Root ganglion neuron 2 75.00 Quite High
Brush evoked pain 42 65.92 Quite High
allodynia 30 45.60 Quite Low
nociceptor 4 34.72 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 256 99.68 Very High Very High Very High
Pain 143 96.16 Very High Very High Very High
Nociception 4 93.36 High High
Neuropathic Pain 124 86.28 High High
Nervous System Injury 38 76.72 Quite High
Ganglion Cysts 44 75.00 Quite High
Stress 4 63.52 Quite High
Rupture 1 56.56 Quite High
Targeted Disruption 2 48.24 Quite Low
Hypersensitivity 8 38.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For Scn11a, expression was reduced in all strains, with the degree of reduction minimal in animals that exhibited a high level of ongoing pain behavior and maximal in strains with minimal ongoing pain.
Negative_regulation (reduced) of Gene_expression (expression) of Scn11a associated with pain and sprains and strains
1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.00 Pain Relevance 0.59
The first two code for voltage sensitive Na+ channel ?
Negative_regulation (sensitive) of Gene_expression (channel) of Na
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.92 Pain Relevance 0.49
Functional expression of I(NaN) declined with time after cell dissociation and recovered during culture, implying that Na(v)1.9 may be regulated dynamically by trophic factors or depend on subtle environmental factors for its survival.
Negative_regulation (declined) of Gene_expression (expression) of NaN
3) Confidence 0.32 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 15290301 Disease Relevance 0.20 Pain Relevance 0.22

General Comments

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