INT120525

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SLCO1B3) plasma membrane (SLCO1B3) transmembrane transport (SLCO1B3)
cytoplasm (SLCO1B3)
Anatomy Link Frequency
hepatocytes 1
bile 1
SLCO1B3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 34 98.64 Very High Very High Very High
imagery 180 72.20 Quite High
Opioid 1 50.00 Quite Low
fibrosis 14 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 64 99.56 Very High Very High Very High
Cancer 48 99.36 Very High Very High Very High
Hemangioma 22 90.24 High High
Metastasis 52 51.28 Quite High
Cirrhosis 22 5.00 Very Low Very Low Very Low
Focal Nodular Hyperplasia 20 5.00 Very Low Very Low Very Low
Adenoma 16 5.00 Very Low Very Low Very Low
Liver Cancer 16 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OATP1B3 expression was constant in SC human hepatocytes.
Gene_expression (expression) of OATP1B3 in hepatocytes
1) Confidence 0.57 Published 2004 Journal Pharm. Res. Section Body Doc Link 15290872 Disease Relevance 0 Pain Relevance 0
HCCs with gadoxetic acid uptake overexpressed OATP1B3 compared with HCCs without gadoxetic acid uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001).
Neg (without) Gene_expression (overexpressed) of OATP1B3
2) Confidence 0.27 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.65 Pain Relevance 0.18
The study elegantly revealed that uptake of gadoxetic acid in HCC is determined by the expression of OATP1B3 rather than by tumor differentiation or bile production.
Spec (determined) Gene_expression (expression) of OATP1B3 in bile associated with bile, cancer and hepatocellular cancer
3) Confidence 0.27 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.83 Pain Relevance 0.15

General Comments

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