INT120529

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.32
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
hepatocytes 1
lung 1
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 31 99.02 Very High Very High Very High
Bile 67 97.84 Very High Very High Very High
dexamethasone 1 97.84 Very High Very High Very High
Analgesic 3 96.56 Very High Very High Very High
Inflammation 28 95.80 Very High Very High Very High
Kinase C 1 94.72 High High
Perioperative pain 3 93.88 High High
rheumatoid arthritis 5 93.08 High High
Cancer pain 3 91.72 High High
methotrexate 15 90.20 High High
Disease Link Frequency Relevance Heat
Gallstones 23 99.86 Very High Very High Very High
Cancer 11 99.48 Very High Very High Very High
Breast Cancer 8 99.36 Very High Very High Very High
Lung Cancer 3 96.58 Very High Very High Very High
INFLAMMATION 31 95.80 Very High Very High Very High
Post Operative Pain 3 93.88 High High
Rheumatoid Arthritis 5 93.08 High High
Cancer Pain 3 91.72 High High
Asthma 1 80.76 Quite High
Biliary Liver Cirrhosis 246 76.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A549 cells (non-small-cell lung cancer cell line) were challenged with glucocorticoids (dexamethasone, hydrocortisone and prednisone) at physiologically and therapeutically relevant concentrations for 24h and changes in MRP2 and MRP3 expression were followed on four levels: promoter regulation (luciferase reporter constructs), mRNA level (semi-quantitative real-time PCR), protein level (Western blotting) and activity (drug resistance and cellular transport of the model substrate calcein).
Positive_regulation (changes) of MRP2 in lung associated with lung cancer and dexamethasone
1) Confidence 0.49 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.43 Pain Relevance 0.13
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.
Positive_regulation (stimulation) of ABCC2 associated with breast cancer and diclofenac
2) Confidence 0.49 Published 2009 Journal Drug Metab. Dispos. Section Title Doc Link 18845662 Disease Relevance 0.55 Pain Relevance 0.76
Phenylbutazone stimulated MRP2 and celecoxib MRP4 transport at low concentrations and inhibited both transporters at high concentration.
Positive_regulation (stimulated) of MRP2
3) Confidence 0.47 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.18 Pain Relevance 0.72
Expression levels of P-gp increased slightly in both species over days in culture; similar expression was observed for MRP2 in SC human hepatocytes.
Positive_regulation (observed) of MRP2 in hepatocytes
4) Confidence 0.43 Published 2004 Journal Pharm. Res. Section Body Doc Link 15290872 Disease Relevance 0 Pain Relevance 0
Moreover, stimulation of MRP2 activity in tumors may lead to increased efflux of chemotherapeutic drugs and thereby drug resistance.
Positive_regulation (stimulation) of MRP2 associated with cancer
5) Confidence 0.39 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 18845662 Disease Relevance 0.32 Pain Relevance 0.28
We further found that the uricosuric drug benzbromarone stimulated MRP2 at an even lower concentration, having maximal stimulatory activity at only 2 microM.
Positive_regulation (stimulated) of MRP2
6) Confidence 0.37 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 18845662 Disease Relevance 0.45 Pain Relevance 0.66
In an animal model of cholestasis, UDCA increases the density of Bsep and Mrp2 in the canalicular membrane of the rat by stimulating transporter targeting and insertion into the membrane [232] by a cooperative protein kinase C ?
Positive_regulation (increases) of Mrp2 associated with kinase c and gallstones
7) Confidence 0.18 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.40

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