INT12054

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 23.20
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MIA3)
Anatomy Link Frequency
plasma 7
pancreatic islets 2
blood 2
liver 1
nerve 1
MIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 45 100.00 Very High Very High Very High
Somatostatin 13 100.00 Very High Very High Very High
Sumatriptan 6 99.70 Very High Very High Very High
Bile 1 99.04 Very High Very High Very High
cytokine 9 98.92 Very High Very High Very High
diabetic neuropathy 32 98.24 Very High Very High Very High
tolerance 25 98.20 Very High Very High Very High
narcan 9 97.38 Very High Very High Very High
peripheral neuropathy 4 97.12 Very High Very High Very High
antagonist 4 94.36 High High
Disease Link Frequency Relevance Heat
Pancreatitis 52 100.00 Very High Very High Very High
Diabetes Mellitus 570 99.98 Very High Very High Very High
Weight Loss 8 99.60 Very High Very High Very High
Generalized Anxiety Disorder 3 99.56 Very High Very High Very High
Obesity 34 99.36 Very High Very High Very High
Hypoglycemia 304 98.64 Very High Very High Very High
Impaired Glucose Tolerance 18 98.52 Very High Very High Very High
Diabetic Neuropathy 44 98.24 Very High Very High Very High
Neuropathy 92 97.64 Very High Very High Very High
Peripheral Neuropathy 4 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma C-peptide levels were reduced postoperatively but the difference was not significant.
Negative_regulation (reduced) of C-peptide in Plasma
1) Confidence 0.45 Published 1997 Journal Am. J. Surg. Section Body Doc Link 9337159 Disease Relevance 0 Pain Relevance 0
Basal hypoinsulinemia and reduction of the C-peptide level revealed only in patients suffering of chronic pancreatitis with secondary diabetes mellitus.
Negative_regulation (reduction) of C-peptide associated with diabetes mellitus and chronic pancreatitis
2) Confidence 0.38 Published 1990 Journal Vrach Delo Section Abstract Doc Link 2098992 Disease Relevance 0.55 Pain Relevance 0.36
Obese subjects showed an exaggerated suppression of insulin and C-peptide and a slight decrease of glucose.
Negative_regulation (suppression) of C-peptide associated with obesity
3) Confidence 0.26 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2958673 Disease Relevance 0.47 Pain Relevance 0.21
A ten-day treatment with naloxone (1.2 mg twice a day) did not change the metabolic and hormonal responses to an oral glucose load (75 g) in lean but significantly inhibited the insulin and C-peptide responses to glucose in obese people.
Negative_regulation (inhibited) of C-peptide associated with obesity and narcan
4) Confidence 0.19 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2958673 Disease Relevance 0.50 Pain Relevance 0.28
In the case of type 1 diabetes, available data suggest that C-peptide deficiency is an important
Negative_regulation (deficiency) of C-peptide associated with diabetes mellitus
5) Confidence 0.10 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 1.72 Pain Relevance 0.09
C-peptide deficiency, are likely to be of importance for the progression of
Negative_regulation (deficiency) of C-peptide
6) Confidence 0.10 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 1.27 Pain Relevance 0.05
Sumatriptan significantly decreased the mean plasma levels of somatostatin, glucagon, pancreatic polypeptide, insulin and C-peptide (P < 0.001) and also significantly decreased mean and peak plasma levels of insulin after an oral glucose challenge (P < 0.02 and P = 0.04, respectively) without affecting glucose homeostasis.
Negative_regulation (decreased) of C-peptide in plasma associated with sumatriptan and somatostatin
7) Confidence 0.10 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486164 Disease Relevance 0.09 Pain Relevance 0.69
replacement dose to patients lacking endogenous C-peptide results in
Negative_regulation (lacking) of C-peptide
8) Confidence 0.09 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.40 Pain Relevance 0.03
nerve function following C-peptide replacement therapy may indicate a new potential
Negative_regulation (following) of C-peptide in nerve
9) Confidence 0.09 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.74 Pain Relevance 0.08
Acute insulin and C-peptide responses to intravenous pulses of different glucose amounts (0.33 g/kg and 5 g) and arginine (3 g) were significantly reduced by beta-endorphin infusion (P less than .01).
Negative_regulation (reduced) of C-peptide
10) Confidence 0.09 Published 1988 Journal Diabetes Section Abstract Doc Link 2970411 Disease Relevance 0 Pain Relevance 0
In lean people, there was a slight trend for insulin and C-peptide concentrations to decrease below baseline values with no glucose change.
Neg (no) Negative_regulation (decrease) of C-peptide
11) Confidence 0.08 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2958673 Disease Relevance 0.40 Pain Relevance 0.22
Plasma glucose was significantly raised by all three doses, whereas serum IRI and C-peptide were decreased and serum FFA was significantly increased only after loperamide 8 and 16 mg; serum PRL, GH, LH and FSH did not change.
Negative_regulation (decreased) of C-peptide in Plasma
12) Confidence 0.08 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6797827 Disease Relevance 0.09 Pain Relevance 0.40
effects of C-peptide on SMCs were inhibited by a specific inhibitor of
Negative_regulation (inhibited) of C-peptide
13) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.43 Pain Relevance 0.03
Serum C-peptide levels showed a moderate decline from baseline levels after s.c. injection of the different insulin formulations in all cases, including the different doses of ultra-fast insulin (data not shown).
Negative_regulation (decline) of C-peptide
14) Confidence 0.04 Published 2008 Journal Diabetologia Section Body Doc Link PMC2516197 Disease Relevance 0 Pain Relevance 0
-cells of pancreatic islets, as shown by the lower suppression of C-peptide.
Negative_regulation (suppression) of C-peptide in pancreatic islets
15) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.51 Pain Relevance 0
By the end of the study, however, C-peptide concentrations returned to basal values and were suppressed in the euglycemia┬ľamino acid and hypoglycemia┬ľamino acid studies, respectively.
Negative_regulation (suppressed) of C-peptide associated with hypoglycemia
16) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.16 Pain Relevance 0
Nevertheless, C-peptide levels decreased later in the treated group, although the change was less pronounced than in the placebo group.
Negative_regulation (decreased) of C-peptide
17) Confidence 0.04 Published 2008 Journal Diabetic Medicine Section Body Doc Link PMC2701557 Disease Relevance 0.36 Pain Relevance 0.08
The finding of diminished plasma C-peptide levels suggests that chronic pancreatitis is associated with an impaired B-cell function even in the absence of overt diabetes.
Negative_regulation (diminished) of C-peptide in B-cell associated with diabetes mellitus and chronic pancreatitis
18) Confidence 0.03 Published 1988 Journal Dig. Dis. Sci. Section Abstract Doc Link 3286157 Disease Relevance 0.52 Pain Relevance 0.45
[Effect of food on blood levels of insulin, glucagon and C-peptide in gastroduodenal pathology].
Negative_regulation (levels) of C-peptide in blood
19) Confidence 0.03 Published 1992 Journal Vopr Pitan Section Title Doc Link 1621373 Disease Relevance 0.51 Pain Relevance 0.07
Diminished blood levels of insulin and C-peptide, inhibited response to pancreozymin registered in the patients may be indicative of symptomatic diabetes onset.
Negative_regulation (Diminished) of C-peptide in blood associated with bile and diabetes mellitus
20) Confidence 0.02 Published 1989 Journal Klin Med (Mosk) Section Abstract Doc Link 2681994 Disease Relevance 1.31 Pain Relevance 0.22

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