INT120547

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2006
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.12
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prdx5) oxidoreductase activity (Prdx5) peroxisome (Prdx5)
cytoplasm (Prdx5)
Anatomy Link Frequency
epithelium 3
plasma 1
leukocytes 1
Prdx5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 161 98.28 Very High Very High Very High
cytokine 12 65.12 Quite High
spinal inflammation 6 50.00 Quite Low
anesthesia 4 18.64 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 153 98.28 Very High Very High Very High
Low Back Pain 6 73.92 Quite High
Stress 18 72.44 Quite High
Acute Monocytic Leukemia 4 70.36 Quite High
Toxicity 8 51.44 Quite High
Lung Injury 8 6.88 Low Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low
Pneumonia 12 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our second aim was to use an in vivo model of inflammation to investigate whether changes of transcription or translation of PRXV in the tracheal epithelium, if they occurred, were a direct response to bacterial pathogen lipopolysaccharide (LPS) by these cells or whether the increased level of PRXV was induced by leukocyte migration.
Spec (whether) Positive_regulation (induced) of PRXV in epithelium associated with inflammation
1) Confidence 0.67 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.58 Pain Relevance 0.30
Our second aim was to use an in vivo model of inflammation to investigate whether changes of transcription or translation of PRXV in the tracheal epithelium, if they occurred, were a direct response to bacterial pathogen lipopolysaccharide (LPS) by these cells or whether the increased level of PRXV was induced by leukocyte migration.
Spec (whether) Positive_regulation (increased) of PRXV in epithelium associated with inflammation
2) Confidence 0.67 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.58 Pain Relevance 0.30
In rats, neither the presence of endotoxins nor f-MLP-induced migration of leukocytes in the tracheal epithelium changed mRNA levels of PRXV; f-MLP slightly increased expression of PRXV protein in the tracheal epithelium.
Neg (neither) Positive_regulation (changed) of PRXV in epithelium
3) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.42 Pain Relevance 0.17
In mice, bacterial inflammation of the lung resulted in a massive influx of leukocytes, which were the source of the increased PRXV in the lung tissues.
Positive_regulation (increased) of PRXV in leukocytes associated with inflammation
4) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.39 Pain Relevance 0.16
RESULTS: There were significant increases in plasma MPO activity and AOPP but decreases in thiol levels in the total AS patient group and in the subgroups, compared with controls.
Positive_regulation (increases) of AOPP in plasma
5) Confidence 0.03 Published 2004 Journal Rheumatology (Oxford) Section Body Doc Link 15292529 Disease Relevance 0.15 Pain Relevance 0

General Comments

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