INT120551

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.73
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rock2) cytoskeleton (Rock2) nucleus (Rock2)
kinase activity (Rock2) cytoplasm (Rock2)
Anatomy Link Frequency
nerve 1
kidney 1
Rock2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Antinociceptive 6 99.74 Very High Very High Very High
Kinase C 4 97.76 Very High Very High Very High
Thermal hyperalgesia 4 97.18 Very High Very High Very High
Inflammation 77 96.52 Very High Very High Very High
qutenza 5 96.40 Very High Very High Very High
antagonist 7 95.80 Very High Very High Very High
ischemia 26 94.84 High High
agonist 12 92.60 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 97.18 Very High Very High Very High
INFLAMMATION 90 96.52 Very High Very High Very High
Fibrosis 2 95.80 Very High Very High Very High
Cv Unclassified Under Development 26 94.84 High High
Reperfusion Injury 4 94.48 High High
Injury 164 90.96 High High
Targeted Disruption 15 89.88 High High
Pruritus 3 82.04 Quite High
Neuropathic Pain 3 75.00 Quite High
Eczema 4 73.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This calcium desensitization is not related to inhibition of Rho-kinase or activation of MLCP.
Negative_regulation (inhibition) of Rho-kinase
1) Confidence 0.52 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19919833 Disease Relevance 0 Pain Relevance 0.10
Y-27632 (1 mg/kg, an inhibitor of Rho-associated protein kinase (ROCK)), was found to suppress SPC-induced scratching.
Negative_regulation (inhibitor) of Rho-associated protein kinase
2) Confidence 0.48 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18289521 Disease Relevance 0.16 Pain Relevance 0.31
Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice.
Negative_regulation (inhibitor) of Rho-kinase associated with analgesic and antinociceptive
3) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16750189 Disease Relevance 0.05 Pain Relevance 0.57
The possible antinociceptive effect of a Rho-kinase inhibitor, (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632), was investigated in mice by using the hot-plate and abdominal constriction response (writhing) tests.
Negative_regulation (inhibitor) of Rho-kinase associated with antinociceptive
4) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16750189 Disease Relevance 0 Pain Relevance 0.13
Additionally, LPA-induced ISRs were abolished by Y-27632, an inhibitor of Rho-associated protein kinase (ROCK).
Negative_regulation (inhibitor) of Rho-associated protein kinase
5) Confidence 0.41 Published 2004 Journal Pharmacology Section Abstract Doc Link 15292655 Disease Relevance 0.15 Pain Relevance 0.14
Interestingly, thermal hyperalgesia induced by nerve ligation in mice was significantly suppressed by repeated i.t. post-treatment with fasudil, which possesses the inhibitory effect of several protein kinases including PKC and Rho kinase.
Negative_regulation (effect) of Rho kinase in nerve associated with thermal hyperalgesia
6) Confidence 0.27 Published 2007 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 17879593 Disease Relevance 0.50 Pain Relevance 0.81
Inhibition of Rho kinase with the renally targeted Y27632-lysozyme conjugate strongly inhibits tubular damage, inflammation, and fibrogenesis induced by ischemia/reperfusion injury indicated by reduced staining of the dedifferentiation marker kidney injury marker-1 (KIM-1) and increased E-cadherin relative to controls [29].
Negative_regulation (Inhibition) of Rho kinase in kidney associated with fibrosis, reperfusion injury, inflammation, ischemia and injury
7) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.65 Pain Relevance 0.30
Isometric contraction in response to MCh was measured in the presence or absence of selective inhibitors of Rho kinase (Y-27632, 1 ?
Negative_regulation (inhibitors) of Rho kinase
8) Confidence 0.02 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.22 Pain Relevance 0.17

General Comments

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