INT120563

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 56
Total Number 58
Disease Relevance 46.19
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Anatomy Link Frequency
lung 10
rectum 4
enterocytes 4
neck 3
Atlas 2
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 16 99.84 Very High Very High Very High
fibrosis 29 95.64 Very High Very High Very High
Central nervous system 31 94.16 High High
positron emission tomography 88 87.56 High High
Potency 19 82.48 Quite High
Inflammatory response 1 75.00 Quite High
Kinase C 17 72.84 Quite High
imagery 97 50.00 Quite Low
palliative 15 50.00 Quite Low
anesthesia 16 48.96 Quite Low
Disease Link Frequency Relevance Heat
Lung Cancer 285 100.00 Very High Very High Very High
Adenocarcinoma 194 99.92 Very High Very High Very High
Non-small-cell Lung Cancer 621 99.86 Very High Very High Very High
Breast Cancer 99 99.86 Very High Very High Very High
Pancreatic Cancer 1308 99.84 Very High Very High Very High
Malignant Neoplastic Disease 222 99.84 Very High Very High Very High
Pancreatitis 28 99.84 Very High Very High Very High
Solid Tumor 160 99.78 Very High Very High Very High
Cancer 2465 99.70 Very High Very High Very High
Metastasis 216 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, Ueda et al demonstrated that cytoplasmic EGFR overexpression by immunohistochemistry was associated with higher grade tumors and shorter survival in a study of 76 archived cases of pancreatic ductal carcinoma (Ueda et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with pancreatic ductal carcinoma and cancer
1) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.99 Pain Relevance 0
While the clinical focus of these agents has been on solid tumors with high levels of EGFR expression whose malignant phenotypes are known to be dependent on EGFR signaling, EGFR expression in and of itself may not be a reliable indicator of the potential antitumor activity of either class of agents, as will be discussed later.
Positive_regulation (levels) of Gene_expression (expression) of EGFR associated with malignant neoplastic disease and solid tumor
2) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.37 Pain Relevance 0
Similar to a number of other malignancies, EGFR has been shown to be overexpressed in pancreatic cancers (Yamanaka et al 1993; Arteaga 2001; Tobita et al 2003; Grandis and Sok 2004; Marshall 2006).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with pancreatic cancer
3) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.71 Pain Relevance 0
Despite the current gaps in our knowledge, the evidence of EGFR overexpression in pancreatic cancer specimens, combined with convincing in vitro data demonstrating the oncogenic potential of EGFR activation, together support a role for EGFR activation in the progression of this malignancy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with malignant neoplastic disease and pancreatic cancer
4) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 1.00 Pain Relevance 0
EGFR overexpression with resultant increase in EGFR signaling may be associated with metastatic potential and decreased survival in patients with pancreatic cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with pancreatic cancer
5) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.81 Pain Relevance 0
In addition to overexpression of EGFR, autocrine stimulation of the receptor may also play a role in the pathogenesis of pancreatic cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with pancreatic cancer
6) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.99 Pain Relevance 0
Expression of ubiquitylated Egfr (Egfr-Ub) was increased in Min/+ enterocytes and tumors.
Positive_regulation (increased) of Gene_expression (Expression) of Egfr in enterocytes associated with cancer
7) Confidence 0.68 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.15 Pain Relevance 0
Head and neck tumors have a high rate of EGFR overexpression [52], which may suggest that these tumors as a class are more EGFR-dependent than other tumor types.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR in neck associated with cancer
8) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716529 Disease Relevance 0.80 Pain Relevance 0
Tyrosine kinase receptors such as members of the epidermal growth factor receptor family and their respective ligands are frequently overexpressed in pancreatic cancer as well as in chronic pancreatitis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of epidermal growth factor receptor associated with pancreatic cancer and chronic pancreatitis
9) Confidence 0.67 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.35 Pain Relevance 0.14
Studies have shown that EGFR and HER-2 protein overexpression is present in 43-89%, and 30-40% lung cancer specimens, respectively [2].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR in lung associated with lung cancer
10) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.04 Pain Relevance 0
In our study, however, the respective median overall survival times for our patients under 55 years of age whose tumors expressed neither type of EGFR, overexpressed wild type EGFR or expressed EGFRvIII, were not statistically different.
Neg (neither) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with cancer
11) Confidence 0.64 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.27 Pain Relevance 0
Future directions for EGFR inhibitor therapy in pancreatic cancer
Positive_regulation (therapy) of Gene_expression (therapy) of EGFR associated with pancreatic cancer
12) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 1.07 Pain Relevance 0
Future directions for EGFR inhibitor therapy in pancreatic cancer
Positive_regulation (directions) of Gene_expression (therapy) of EGFR associated with pancreatic cancer
13) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 1.07 Pain Relevance 0
EGFR overexpression with resultant increase in EGFR signaling may be associated with metastatic potential and decreased survival in patients with pancreatic cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with pancreatic cancer
14) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.81 Pain Relevance 0
Of note, EGFR overexpression was not required for enrollment.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR
15) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.97 Pain Relevance 0
FISH and PCR analysis have also been used to evaluate tumor specimens for EGFR gene amplification and presumed resulting overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR gene associated with cancer
16) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.72 Pain Relevance 0
Though hypothesized to increase transcriptional efficiency of EGFR and thus lead to overexpression, the polymorphism was not associated with any increased expression of downstream molecular markers of EGFR pathway activation.
Positive_regulation (increased) of Gene_expression (expression) of EGFR
17) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.72 Pain Relevance 0
We report here RNAi induced effective silencing of the epidermal growth factor receptor (EGFR) gene, which is over expressed in NSCLC.
Positive_regulation (induced) of Gene_expression (expressed) of epidermal growth factor receptor associated with non-small-cell lung cancer
18) Confidence 0.50 Published 2005 Journal Genet Vaccines Ther Section Abstract Doc Link PMC1187910 Disease Relevance 1.07 Pain Relevance 0
As shown in Fig. 4, we demonstrated that cells transfected with dsRNA-EGFR were more sensitive to cisplatin than various control groups.
Positive_regulation (transfected) of Gene_expression (transfected) of dsRNA-EGFR
19) Confidence 0.50 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.72 Pain Relevance 0
We report here RNAi induced effective silencing of the epidermal growth factor receptor (EGFR) gene, which is over expressed in NSCLC.
Positive_regulation (induced) of Gene_expression (expressed) of EGFR associated with non-small-cell lung cancer
20) Confidence 0.50 Published 2005 Journal Genet Vaccines Ther Section Abstract Doc Link PMC1187910 Disease Relevance 1.07 Pain Relevance 0

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