INT12057

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.92
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 2
muscle 2
adipocytes 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 10 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
Opioid 1 98.44 Very High Very High Very High
peptic ulcer disease 1 72.68 Quite High
Endogenous opioid 2 67.52 Quite High
antagonist 1 65.28 Quite High
cytokine 2 58.16 Quite High
Pain 10 25.00 Low Low
agonist 2 15.76 Low Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 9 100.00 Very High Very High Very High
Obesity 29 98.60 Very High Very High Very High
Polycystic Ovary Syndrome 9 97.12 Very High Very High Very High
Hypothermia 54 94.48 High High
Hyperinsulinism 3 92.64 High High
Stress 4 91.48 High High
Ulcers 3 91.40 High High
Acid Base Imbalance 1 90.20 High High
Peptic Ulcer 1 88.92 High High
Arrhythmia Under Development 2 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperglycaemia due to reduction of insulin secretion and insulin resistance should be controlled by close monitoring and insulin therapy.
Regulation (controlled) of Negative_regulation (reduction) of insulin associated with insulin resistance
1) Confidence 0.40 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2998647 Disease Relevance 1.14 Pain Relevance 0
Although more research is needed on the potential role for TNF-alpha inhibition of insulin action, elevated TNF-alpha production after muscle damage may impair insulin signal transduction.
Regulation (role) of Negative_regulation (inhibition) of insulin in muscle
2) Confidence 0.39 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.28 Pain Relevance 0.03
Usually, the effect of the NPH insulin is very slow and continues for a long
Regulation (continues) of Negative_regulation (effect) of insulin
3) Confidence 0.39 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.48 Pain Relevance 0
However, pharmacological PDE-3B inhibition or PDE-3B stimulation through insulin did not affect ANP-induced lipolysis in isolated adipocytes (32,34).
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of insulin in adipocytes associated with obesity
4) Confidence 0.27 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.38 Pain Relevance 0
Naloxone had no effect on the hormonal response except for a prolonged reduction of insulin and glucose levels following high dose CCK + naloxone.
Neg (no) Regulation (effect) of Neg (except) Negative_regulation (reduction) of insulin associated with narcan
5) Confidence 0.18 Published 1991 Journal Z Gastroenterol Section Abstract Doc Link 1714670 Disease Relevance 0 Pain Relevance 0.34
Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects.
Regulation (effect) of Negative_regulation (blockade) of insulin associated with obesity, narcan, polycystic ovary syndrome, opiate and opioid
6) Confidence 0.06 Published 1990 Journal Fertil. Steril. Section Abstract Doc Link 1697813 Disease Relevance 1.14 Pain Relevance 0.32
[Effect of food on blood levels of insulin, glucagon and C-peptide in gastroduodenal pathology].
Regulation ([Effect) of Negative_regulation (levels) of insulin in blood
7) Confidence 0.03 Published 1992 Journal Vopr Pitan Section Title Doc Link 1621373 Disease Relevance 0.50 Pain Relevance 0.07

General Comments

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