INT120595

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.83
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (ABCC4) plasma membrane (ABCC4) transmembrane transport (ABCC4)
biological_process (ABCC4)
Anatomy Link Frequency
liver 1
platelets 1
ABCC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.72 Very High Very High Very High
diclofenac 1 96.20 Very High Very High Very High
adenocard 2 91.68 High High
methotrexate 11 90.20 High High
cINOD 7 89.76 High High
Potency 1 78.68 Quite High
Bile 2 61.04 Quite High
Inflammation 1 51.28 Quite High
Disease Link Frequency Relevance Heat
Disease 3 99.64 Very High Very High Very High
Overdose 6 99.52 Very High Very High Very High
Biliary Liver Cirrhosis 16 98.92 Very High Very High Very High
Syndrome 1 97.44 Very High Very High Very High
Breast Cancer 2 84.20 Quite High
INFLAMMATION 4 75.00 Quite High
Acute Liver Failure 2 75.00 Quite High
Liver Failure 2 69.52 Quite High
Injury 4 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Positive_regulation (increased) of MRP4 associated with biliary liver cirrhosis and disease
1) Confidence 0.51 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.36 Pain Relevance 0.57
Compared with normal liver specimens, MRP1 and MRP4 mRNA levels were elevated after APAP overdose and in PBC.
Positive_regulation (elevated) of MRP4 in liver associated with biliary liver cirrhosis, paracetamol and overdose
2) Confidence 0.51 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.19 Pain Relevance 0.53
Furthermore, an altered distribution of MRP4 was observed in platelets from a patient with Hermansky-Pudlak syndrome with defective delta-granules.
Positive_regulation (distribution) of MRP4 in platelets associated with syndrome
3) Confidence 0.50 Published 2004 Journal Blood Section Abstract Doc Link 15297306 Disease Relevance 0.10 Pain Relevance 0.08
Phenylbutazone stimulated MRP2 and celecoxib MRP4 transport at low concentrations and inhibited both transporters at high concentration.
Positive_regulation (stimulated) of MRP4
4) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.18 Pain Relevance 0.72

General Comments

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