INT120598

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.49
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (ABCC4) plasma membrane (ABCC4) transmembrane transport (ABCC4)
biological_process (ABCC4)
Anatomy Link Frequency
platelet 2
plasma 1
ABCC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 22 100.00 Very High Very High Very High
cINOD 14 100.00 Very High Very High Very High
diclofenac 2 97.12 Very High Very High Very High
adenocard 4 77.08 Quite High
Potency 1 72.76 Quite High
Inflammation 1 45.36 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 96.72 Very High Very High Very High
Syndrome 2 75.44 Quite High
Disease 1 45.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate a function of MRP4 in platelet mediator storage and inhibition of MRP4 may represent a novel mechanism for inhibition of platelet function by some anti-inflammatory drugs.
Negative_regulation (inhibition) of MRP4 in platelet associated with inflammation and cinod
1) Confidence 0.59 Published 2004 Journal Blood Section Abstract Doc Link 15297306 Disease Relevance 0.17 Pain Relevance 0.13
Salicylate and indomethacin were predicted to inhibit MRP4 at clinical plasma concentrations.
Negative_regulation (inhibit) of MRP4 in plasma
2) Confidence 0.55 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17578901 Disease Relevance 0.07 Pain Relevance 0.69
The results indicate a function of MRP4 in platelet mediator storage and inhibition of MRP4 may represent a novel mechanism for inhibition of platelet function by some anti-inflammatory drugs.
Negative_regulation (function) of MRP4 in platelet associated with inflammation and cinod
3) Confidence 0.43 Published 2004 Journal Blood Section Abstract Doc Link 15297306 Disease Relevance 0.17 Pain Relevance 0.13
Our data suggest that the inhibition by NSAIDs of renal MTX efflux via MRP2 and MRP4 is a potential new site and mechanism contributing to the overall interaction between these drugs.
Negative_regulation (inhibition) of MRP4 associated with cinod and methotrexate
4) Confidence 0.42 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.07 Pain Relevance 0.65

General Comments

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