INT120599

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Anatomy Link Frequency
immune cells 1
Tlr7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 31 98.12 Very High Very High Very High
Inflammation 32 93.44 High High
spastic colon 68 76.00 Quite High
Opioid 3 75.00 Quite High
abdominal pain 4 73.28 Quite High
nud 12 51.00 Quite High
Catecholamine 4 5.00 Very Low Very Low Very Low
noradrenaline 4 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 1 99.40 Very High Very High Very High
Stress 98 94.72 High High
Sprains And Strains 24 93.64 High High
INFLAMMATION 32 93.44 High High
Genetic Predisposition To Disease 32 91.04 High High
Infection 14 81.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

68 76.00 Quite High
Cancer 3 75.00 Quite High
Abdominal Pain 4 73.28 Quite High
Syndrome 2 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR7 is known to bind to ssRNA from viruses [43] and TLR9 is known to bind to methylated DNA from bacteria and viruses [44] while there is no known ligand for TLR10 at present.
TLR7 Binding (bind) of
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.78 Pain Relevance 0.26
TLR4 binds lipopolysaccharide (LPS) in gram-negative bacteria and TLR7 binds single stranded RNA (ssRNA) from viruses.
TLR7 Binding (binds) of
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.85 Pain Relevance 0.58
Via interaction with Toll-like receptor 7 on immune cells, imiquimod induces local production of cytokines, such as interferon (IFN)-alpha.
Toll-like receptor 7 Binding (interaction) of in immune cells associated with cytokine
3) Confidence 0.03 Published 2004 Journal Clin. Cancer Res. Section Abstract Doc Link 15297396 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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