INT120603

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.57
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cntf) cytosol (Cntf) extracellular space (Cntf)
growth (Cntf) nucleus (Cntf) cytoplasm (Cntf)
Anatomy Link Frequency
spinal cord 2
neurons 2
ciliary 2
Cntf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 195 98.08 Very High Very High Very High
Dorsal column 60 96.76 Very High Very High Very High
trk B 3 82.88 Quite High
bDMF 6 82.32 Quite High
Trk A 4 80.64 Quite High
Nerve growth factor 1 80.08 Quite High
Central nervous system 59 60.80 Quite High
intrathecal 1 51.84 Quite High
allodynia 46 50.00 Quite Low
dorsal root ganglion 14 44.64 Quite Low
Disease Link Frequency Relevance Heat
Injury 314 99.68 Very High Very High Very High
Spinal Cord Injury 176 98.08 Very High Very High Very High
Apoptosis 87 95.64 Very High Very High Very High
Diabetes Insipidus 22 93.96 High High
Sensation Disorders 4 79.12 Quite High
Optic Nerve Injuries 2 67.88 Quite High
Neuropathic Pain 86 50.00 Quite Low
Diabetes Mellitus 6 50.00 Quite Low
Ganglion Cysts 16 44.64 Quite Low
Necrosis 6 35.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Failure of GDAsCNTF to promote locomotor functional recovery after spinal cord injury
Negative_regulation (Failure) of GDAsCNTF in spinal cord associated with spinal cord
1) Confidence 0.35 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.11 Pain Relevance 0.28
The failure of both GDAsCNTF and GRPs (see also [14]) to support axon regeneration is in stark contrast to the ability of transplanted GDAsBMP to promote regeneration of endogenous dorsal column axons across spinal cord injuries.
Negative_regulation (failure) of GDAsCNTF in spinal cord associated with spinal cord and dorsal column
2) Confidence 0.35 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.10 Pain Relevance 0.27
A depletion of ciliary neurotrophic factor mediated by the polyol pathway may be involved in the aetiology of thermal hypoalgesia.


Negative_regulation (depletion) of ciliary neurotrophic factor in ciliary
3) Confidence 0.35 Published 2004 Journal Diabetologia Section Body Doc Link 15298349 Disease Relevance 0 Pain Relevance 0
It has been reported that CNTF, Bcl-xL and Caspase inhibitor could increase the survival of rat vasopressin magnocellular neurons in organotypic cluture.
Negative_regulation (inhibitor) of CNTF in neurons
4) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.84 Pain Relevance 0
RESULTS: Thermal hypoalgesia was present after 8 weeks of diabetes and was prevented by insulin treatment, which maintained normoglycaemia, by the aldose reductase inhibitor Statil or by ciliary neurotrophic factor.
Negative_regulation (prevented) of ciliary neurotrophic factor in ciliary
5) Confidence 0.25 Published 2004 Journal Diabetologia Section Body Doc Link 15298349 Disease Relevance 0.08 Pain Relevance 0
Our findings suggest that TPS neurons should be particularly sensitive to GDNF, LIF, and CNTF during the first week p.i., and these are the growth factors most likely to be effective in protecting TPS neurons from apoptosis and maintaining a regenerative response within a CNS environment.
Negative_regulation (sensitive) of CNTF in neurons associated with apoptosis
6) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.44 Pain Relevance 0.23

General Comments

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