INT12061

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 5.52
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LNPEP) peptidase activity (LNPEP) extracellular region (LNPEP)
plasma membrane (LNPEP) intracellular (LNPEP) cell-cell signaling (LNPEP)
Anatomy Link Frequency
cleavage 2
blood 1
plasma 1
LNPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 27 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
beta blocker 1 99.92 Very High Very High Very High
Neuropeptide 11 99.48 Very High Very High Very High
Calcium channel 2 99.32 Very High Very High Very High
Potency 8 97.52 Very High Very High Very High
agonist 8 94.16 High High
Paracetamol 3 93.60 High High
aspirin 4 92.32 High High
Inflammation 51 89.60 High High
Disease Link Frequency Relevance Heat
Pre-eclampsia 92 99.48 Very High Very High Very High
Fatigue 31 99.36 Very High Very High Very High
Cognitive Disorder 10 98.48 Very High Very High Very High
Disease 42 97.52 Very High Very High Very High
Hypertension 101 97.48 Very High Very High Very High
Diabetes Mellitus 58 94.92 High High
Pressure Volume 2 Under Development 11 94.24 High High
Brain Injury 1 93.08 High High
Diabetic Nephropathy 5 90.00 High High
INFLAMMATION 48 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).
Negative_regulation (inhibitors) of insulin regulated aminopeptidase
1) Confidence 0.58 Published 2003 Journal J. Neurochem. Section Title Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.05
In this study, we demonstrate that AT4 receptor ligands, including Ang IV, Nle1-Ang IV, divalinal-Ang IV, and the structurally unrelated LVV-hemorphin-7, are all potent inhibitors of IRAP catalytic activity, as assessed by cleavage of leu-beta-naphthylamide by recombinant human IRAP.
Negative_regulation (inhibitors) of IRAP in cleavage
2) Confidence 0.58 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871575 Disease Relevance 0 Pain Relevance 0
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).
Negative_regulation (inhibitors) of IRAP
3) Confidence 0.58 Published 2003 Journal J. Neurochem. Section Title Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.05
The results suggest that the oxytocic action of prostaglandins may be due, at least in part, to an inhibition of oxytocinase activity.
Negative_regulation (inhibition) of oxytocinase
4) Confidence 0.57 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6267639 Disease Relevance 0 Pain Relevance 0.18
Inhibition of serum oxytocinase activity by prostaglandins.
Negative_regulation (Inhibition) of oxytocinase
5) Confidence 0.57 Published 1981 Journal Prostaglandins Med Section Title Doc Link 6267639 Disease Relevance 0 Pain Relevance 0.16
We propose that the physiological effects of AT4 ligands result, in part, from inhibition of IRAP cleavage of neuropeptides involved in memory processing.
Negative_regulation (inhibition) of IRAP in cleavage associated with neuropeptide
6) Confidence 0.42 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.15
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).
Negative_regulation (inhibitors) of insulin regulated aminopeptidase
7) Confidence 0.42 Published 2003 Journal J. Neurochem. Section Title Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.05
PGE1, PGE2 and PGF2 alpha significantly inhibited serum oxytocinase activity in a dose-related manner and in decreasing order of potency. cGMP, 8-bromo-cGMP, indomethacin, polyphloretin phosphate, hypertonic saline and urea were also active. cAMP, db-cAMP, 8-bromo-cAMP, db-cGMP, 5'-AMP, 5'-ADP, 5'-ATP, 5'-GDP, 5'-GTP, aspirin, sodium salicylate, paracetamol, theophylline and IBMX did not inhibit the enzyme activity.
Negative_regulation (inhibited) of oxytocinase associated with aspirin, paracetamol and potency
8) Confidence 0.41 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6267639 Disease Relevance 0 Pain Relevance 0.18
A technique for complete oxytocinase inhibition has been combined with a rapid serial sampling strategy to determine plasma oxytocin concentrations in twelve women during the early and late first stage and in eight women throughout the second stage of labour.
Negative_regulation (inhibition) of oxytocinase in plasma
9) Confidence 0.35 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1621487 Disease Relevance 0.08 Pain Relevance 0.08
The results of these studies indicate that agents that selectively activate or block the OP4 receptor may represent new potential drugs for the treatment of human diseases.
Negative_regulation (block) of OP4 receptor associated with disease
10) Confidence 0.34 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11906488 Disease Relevance 0.10 Pain Relevance 0.30
These compounds are effective inhibitors of human enkephalin degrading aminopeptidase, microsomal leucine aminopeptidase (EC 3.4.11.2), and cytosolic leucine aminopeptidase (EC 3.4.11.1) at micro- to nanomolar concentrations.
Negative_regulation (inhibitors) of leucine aminopeptidase associated with enkephalin
11) Confidence 0.30 Published 1986 Journal Biochemistry Section Abstract Doc Link 3516217 Disease Relevance 0 Pain Relevance 0.10
These compounds are effective inhibitors of human enkephalin degrading aminopeptidase, microsomal leucine aminopeptidase (EC 3.4.11.2), and cytosolic leucine aminopeptidase (EC 3.4.11.1) at micro- to nanomolar concentrations.
Negative_regulation (inhibitors) of leucine aminopeptidase associated with enkephalin
12) Confidence 0.30 Published 1986 Journal Biochemistry Section Abstract Doc Link 3516217 Disease Relevance 0 Pain Relevance 0.10
The inhibition of cytosolic leucine aminopeptidase has been studied in some detail.
Negative_regulation (inhibition) of leucine aminopeptidase
13) Confidence 0.30 Published 1986 Journal Biochemistry Section Abstract Doc Link 3516217 Disease Relevance 0 Pain Relevance 0.09
Mice deficient in renin, angiotensinogen, ACE, and the type 1 angiotensin receptor (AT1) showed reduced BP, while APA KO mice evidenced a modest hypertension.
Negative_regulation (deficient) of angiotensin receptor associated with hypertension
14) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0
Inhibition of insulin-regulated aminopeptidase (IRAP) has been demonstrated to facilitate memory in rodents, making IRAP a potential target for the development of cognitive enhancing therapies.
Negative_regulation (Inhibition) of IRAP associated with cognitive disorder
15) Confidence 0.18 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523486 Disease Relevance 0.10 Pain Relevance 0
As the severity of preeclampsia progresses, both APA and P-LAP enzyme activity decrease, ultimately becoming lower than that measured during normal pregnancy [42, 44].
Negative_regulation (decrease) of P-LAP associated with pre-eclampsia
16) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.62 Pain Relevance 0.11
Our discovery that peptide inhibitors of insulin-regulated aminopeptidase (IRAP) elicit significant effects on memory acquisition and retrieval provides the basis for the proposition that IRAP is a novel target for the discovery of cognitive enhancers.
Negative_regulation (inhibitors) of insulin-regulated aminopeptidase associated with cognitive disorder
17) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.82 Pain Relevance 0.09
Fatigue has been associated with ACEI, angiotensin receptor antagonists, direct renin inhibitors, beta blockers, calcium channel blockers, and diuretics [46,47].
Negative_regulation (inhibitors) of angiotensin receptor associated with beta blocker, calcium channel, antagonist and fatigue
18) Confidence 0.02 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 1.17 Pain Relevance 0.29
Lercanidipine (10mg/day) is also effective when combined with ACE inhibitor or angiotensin receptor blocker therapy (Guillen et al 2003; Robles et al 2004) and reduces blood pressure more than ?
Negative_regulation (inhibitor) of angiotensin receptor in blood
19) Confidence 0.01 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993952 Disease Relevance 0.54 Pain Relevance 0
An optimized medical treatment consisting of medication such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), and statins plays an important role during rehabilitation.
Negative_regulation (inhibitors) of angiotensin-receptor
20) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762434 Disease Relevance 1.47 Pain Relevance 0.15

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