INT12062

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 1.04
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
placenta 8
myometrium 4
plasma 2
nerve 2
uterine 2
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
addiction 2 99.92 Very High Very High Very High
Neuropeptide 4 98.32 Very High Very High Very High
Dismenorea 12 93.00 High High
analgesia 5 92.00 High High
cytokine 23 89.08 High High
Ventral tegmentum 1 82.56 Quite High
withdrawal 8 68.08 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 10 93.00 High High
Reprotox - General 1 2 91.76 High High
Premature Birth 282 71.28 Quite High
Pre-eclampsia 10 68.64 Quite High
Reprotox - General 3 36 67.72 Quite High
Habitual Abortion 4 67.20 Quite High
INFLAMMATION 46 63.36 Quite High
Infection 100 5.00 Very Low Very Low Very Low
Stress 42 5.00 Very Low Very Low Very Low
Pre-term Labor 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results do not support transfer of oxytocin across the placenta in women.
Positive_regulation (transfer) of Gene_expression (transfer) of oxytocin in placenta
1) Confidence 0.69 Published 1999 Journal Br J Obstet Gynaecol Section Abstract Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.08
It is not known whether human labour is associated with increased fetal oxytocin production or transfer of oxytocin across the placenta.
Spec (whether) Positive_regulation (increased) of Gene_expression (production) of oxytocin in placenta
2) Confidence 0.69 Published 1999 Journal Br J Obstet Gynaecol Section Abstract Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.09
Labour was not associated with an increase in fetal oxytocin production.
Positive_regulation (increase) of Gene_expression (production) of oxytocin
3) Confidence 0.61 Published 1999 Journal Br J Obstet Gynaecol Section Abstract Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.08
However, little is known about the mutual dependence of the oxytocin receptor, oxytocin and 17-beta-estradiol in the nonpregnant myometrium and about the distribution of the oxytocin receptor in the nonpregnant uterus.
Positive_regulation (dependence) of Gene_expression (distribution) of oxytocin in myometrium associated with addiction
4) Confidence 0.50 Published 2003 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 14605818 Disease Relevance 0.09 Pain Relevance 0.14
However, little is known about the mutual dependence of the oxytocin receptor, oxytocin and 17-beta-estradiol in the nonpregnant myometrium and about the distribution of the oxytocin receptor in the nonpregnant uterus.
Positive_regulation (dependence) of Gene_expression (distribution) of oxytocin in myometrium associated with addiction
5) Confidence 0.50 Published 2003 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 14605818 Disease Relevance 0.09 Pain Relevance 0.14
Recent evidence suggests that oxytocin is most important for the initial phase of labour, whereas increased synthesis of PGF2 alpha is essential for the progression of labour.
Positive_regulation (increased) of Gene_expression (synthesis) of oxytocin
6) Confidence 0.50 Published 1984 Journal Br J Obstet Gynaecol Section Abstract Doc Link 6091729 Disease Relevance 0.07 Pain Relevance 0.07
The majority of patients do not demonstrate an increase in plasma oxytocin concentration during the second stage of labour; however, a minority produce a large surge immediately before delivery.
Positive_regulation (increase) of Gene_expression (concentration) of oxytocin in plasma
7) Confidence 0.49 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1621487 Disease Relevance 0.09 Pain Relevance 0.09
It is not known whether human labour is associated with increased fetal oxytocin production or transfer of oxytocin across the placenta.
Spec (whether) Positive_regulation (transfer) of Gene_expression (transfer) of oxytocin in placenta
8) Confidence 0.47 Published 1999 Journal Br J Obstet Gynaecol Section Abstract Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.09
It is not known whether human labour is associated with increased fetal oxytocin production or transfer of oxytocin across the placenta.
Spec (whether) Positive_regulation (increased) of Gene_expression (production) of oxytocin in placenta
9) Confidence 0.44 Published 1999 Journal Br J Obstet Gynaecol Section Abstract Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.09
The authors argue that repeated experience with another player's cooperation can lead to the evaluation of that player as a ‘trustworthy’ person, resulting in an increased production of oxytocin and allowing greater trust.
Positive_regulation (increased) of Gene_expression (production) of oxytocin
10) Confidence 0.07 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581786 Disease Relevance 0 Pain Relevance 0.08
The co-existence of pituitary hormone and neuropeptide secretion, such as growth hormone, prolactin, adrenocorticotropic hormone, thyroid stimulating hormone, triiodothyronine, somatostatin, oxytocin, follicle stimulating hormone, luteinizing hormone, arginine vasopressin, growth hormone releasing hormone, corticotropin releasing hormone, nerve growth factor, vasoactive intestinal peptide, (pro) enkephalin, and beta-endorphin, production of a number of interleukins and growth factors, as well as the expression of receptors for all, by the same RE cell is an unique molecular biological phenomenon.
Positive_regulation (stimulating) of Gene_expression (production) of oxytocin in nerve associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
11) Confidence 0.05 Published 1999 Journal In Vivo Section Abstract Doc Link 10459506 Disease Relevance 0 Pain Relevance 0.29
Estrogens increase the expression of many contraction-associated proteins, including connexin 43, and of oxytocin and prostaglandin receptors; estrogens also promote prostaglandin production and increases myosin light-chain kinase (MLCK, which stimulates myometrial contractions) [3].
Positive_regulation (increase) of Gene_expression (expression) of oxytocin
12) Confidence 0.04 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.14 Pain Relevance 0.18
Myometrial activation occurs in Phase 1 and is characterized by increased expression of myometrial contractile-associated proteins and cellular receptors for oxytocin and prostaglandins, both of which stimulate uterine contractility [12].
Positive_regulation (increased) of Gene_expression (expression) of oxytocin in uterine
13) Confidence 0.04 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.55 Pain Relevance 0.21

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