INT120647

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Context Info
Confidence 0.74
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.10
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SCN8A) transmembrane transport (SCN8A)
Anatomy Link Frequency
neck 1
sperm 1
SCN8A (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.8 18 100.00 Very High Very High Very High
Nav1.6 14 100.00 Very High Very High Very High
Nav1.7 14 100.00 Very High Very High Very High
Nav1.9 8 100.00 Very High Very High Very High
nav1.3 14 98.82 Very High Very High Very High
Nav1.2 10 98.34 Very High Very High Very High
Nav1.1 16 97.86 Very High Very High Very High
Neuropathic pain 1 95.64 Very High Very High Very High
sodium channel 17 93.12 High High
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 95.64 Very High Very High Very High
Sperm Disorder 30 21.80 Low Low
Nociception 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCN8A (Nav1.6) was present in the flagellum principal piece with a faint fluorescence staining being observed around the neck.
Gene_expression (present) of SCN8A in neck associated with nav1.6
1) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.42
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN8A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
2) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.97
Consistent down-regulation of all transcripts was observed, as well as significant changes in the splicing patterns of SCN8A and SCN9A.
Gene_expression (patterns) of SCN8A
3) Confidence 0.55 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302875 Disease Relevance 0.10 Pain Relevance 0.21

General Comments

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