INT120650

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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 6.86
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
neuronal 1
unfertilized eggs 1
cortex 1
prefrontal 1
T lymphocyte 1
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 99.48 Very High Very High Very High
cannabis 112 99.36 Very High Very High Very High
sodium channel 3 96.96 Very High Very High Very High
drug abuse 399 94.08 High High
cocaine 196 93.84 High High
Nucleus accumbens 14 91.48 High High
Inflammation 82 82.88 Quite High
Hippocampus 7 76.24 Quite High
opiate 7 73.60 Quite High
Chronic pancreatitis 39 70.72 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 33 99.60 Very High Very High Very High
Breast Cancer 68 99.58 Very High Very High Very High
Familial Dysautonomia 363 99.52 Very High Very High Very High
Neuropathic Pain 4 99.48 Very High Very High Very High
Dengue Hemorrhagic Fever 205 99.36 Very High Very High Very High
Schizophrenia 14 98.38 Very High Very High Very High
Pancreatitis 69 98.20 Very High Very High Very High
Syndrome 19 94.40 High High
Injury 2 94.20 High High
Drug Dependence 406 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent down-regulation of all transcripts was observed, as well as significant changes in the splicing patterns of SCN8A and SCN9A.
Negative_regulation (down-regulation) of transcripts
1) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302875 Disease Relevance 0.10 Pain Relevance 0.22
Reduced abundance of a number of T-lymphocyte related transcripts at the time of DSS may reflect a feed-back mechanism aimed at limiting an initial early T lymphocyte activation, reported to occur in patients who further progress to severe dengue [96], [97].
Negative_regulation (number) of transcripts in T lymphocyte associated with dengue and dengue hemorrhagic fever
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.59 Pain Relevance 0.08
A number of transcripts encoding proteins regulating intracellular trafficking of secretory pathways were changed, with a predominant increase in transcription of ER/Golgi-related transcripts.
Negative_regulation (number) of transcripts
3) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.24 Pain Relevance 0.40
Transcripts for which expression was decreased were mainly associated with synaptic vesicular trafficking, clathrin-independent endocytosis or transport from the late endosome to the lysosome.
Negative_regulation (decreased) of Transcripts
4) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.05 Pain Relevance 0.22
Studies in human postmortem brain have previously demonstrated a general decrease in calcium/cAMP-related signaling transcripts in frontal and motor cortex of human alcoholics [13], a decrease in adenylate cyclase (AC) type I (AC-I) protein levels and activity in temporal and frontal cortex in alcoholics [22]–[23] and in AC-I mRNA and protein in temporal cortex from heroin addicts [24].
Negative_regulation (decrease) of transcripts in cortex associated with urological neuroanatomy
5) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.55 Pain Relevance 0.18
The significant decrease in CALM1, CALM2 and CAMKIIB transcripts suggest that altered regulation of neuroplasticity and dendritic architecture by calmodulin-regulated pathways could be a common theme in human abuse of cocaine, cannabis and/or phencyclidine.


Negative_regulation (decrease) of transcripts associated with cannabis and cocaine
6) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.19 Pain Relevance 0.16
The lower total number of transcripts identified for cannabis cases was noteworthy.
Negative_regulation (number) of transcripts associated with cannabis
7) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.30 Pain Relevance 0.41
An additional 113 transcripts were significantly changed in Groups I–II only; 44 transcripts, including FIBP, VTN, STOM, ICAM1, SEMA3B, RARG, RARA, were increased, and 68 transcripts, including APOL1, CALM1, CALM2, CAMK2B, GNB2L1, HINT1, RAB9A, CHEK1, PPP2CA and NFKBIA, were decreased.
Negative_regulation (decreased) of transcripts
8) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.18 Pain Relevance 0.15
This is reminiscent of the situation in the prefrontal cortex in schizophrenia, where expression of APOL1, 2 and 4 transcripts were increased [35], and myelin transcripts were decreased [9].
Negative_regulation (decreased) of transcripts in prefrontal associated with schizophrenia
9) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.26 Pain Relevance 0.25
While a heterozygous inactivating CASR mutation leads to FHH, homozygous mutations result in severe neonatal pHPT.
Negative_regulation (inactivating) of mutation associated with hypercalcemia
10) Confidence 0.01 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.50 Pain Relevance 0.07
SpREJ8 transcripts are low in unfertilized eggs, increase to 22 hours and then decrease thereafter, suggesting that this protein is important for blastula formation.
Negative_regulation (decrease) of transcripts in unfertilized eggs
11) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
To investigate the effect of specific inhibition of mutated p53 gene, breast cancer cells harbouring an inactivating p53 mutation were transfected with antisense RNA using a cationic liposome-mediated method.
Negative_regulation (inactivating) of mutation associated with breast cancer
12) Confidence 0.00 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.02 Pain Relevance 0
Thus, these results confirmed a decreased level of IKBKAP transcripts (WT+MU) in FD cells.
Negative_regulation (level) of transcripts associated with familial dysautonomia
13) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.36 Pain Relevance 0
Thus, these results confirmed a decreased level of IKBKAP transcripts (WT+MU) in FD cells.
Negative_regulation (decreased) of transcripts associated with familial dysautonomia
14) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.36 Pain Relevance 0
In order to establish a direct link between low levels of IKBKAP WT transcripts and decreased neuronal populations in FD patients, several groups have investigated transcriptome variations resulting from a reduced level of IKBKAP transcripts using microarray technology [10], [22], [34], [40], [53].
Negative_regulation (reduced) of transcripts in neuronal associated with familial dysautonomia
15) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.15 Pain Relevance 0
1, characterized by blunted and delayed down-regulation of PRL, IGFBP-1, and TF transcripts, which was not associated with a significant reduction in secretion of PRL or IGFBP-1 proteins.
Negative_regulation (down-regulation) of transcripts
16) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0

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