INT120651

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.02
Pain Relevance 8.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
dorsal horn 6
DRGs 4
hippocampus 4
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 454 100.00 Very High Very High Very High
Inflammation 9 99.98 Very High Very High Very High
Dorsal horn 3 99.84 Very High Very High Very High
Hippocampus 48 99.68 Very High Very High Very High
ischemia 386 99.04 Very High Very High Very High
TRP channel 2 96.24 Very High Very High Very High
addiction 6 96.20 Very High Very High Very High
Dorsal horn neuron 15 94.72 High High
Action potential 5 92.96 High High
tolerance 49 91.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.98 Very High Very High Very High
Ganglion Cysts 6 99.20 Very High Very High Very High
Cv Unclassified Under Development 370 99.04 Very High Very High Very High
Apoptosis 35 94.64 High High
Epilepsy 4 94.48 High High
Brain Hemorrhage 22 94.32 High High
Death 63 94.08 High High
Injury 30 92.92 High High
Acidosis 77 91.28 High High
Neurological Disease 2 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, peripheral complete Freund's adjuvant-induced inflammation resulted in increased expression of both ASIC1a and ASIC2a in dorsal horn.
Positive_regulation (resulted) of Gene_expression (expression) of ASIC2a in dorsal horn associated with inflammation and dorsal horn
1) Confidence 0.66 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.87
Furthermore, peripheral complete Freund's adjuvant-induced inflammation resulted in increased expression of both ASIC1a and ASIC2a in dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of ASIC1a in dorsal horn associated with inflammation and dorsal horn
2) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.86
Furthermore, peripheral complete Freund's adjuvant-induced inflammation resulted in increased expression of both ASIC1a and ASIC2a in dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of ASIC2a in dorsal horn associated with inflammation and dorsal horn
3) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.87
The expression of ASIC1a and ASIC1b was increased in the ipsilateral DRGs, whereas the ASIC3 and TRPV1 expression was not changed.
Positive_regulation (increased) of Gene_expression (expression) of ASIC1b in DRGs associated with ganglion cysts
4) Confidence 0.35 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.15 Pain Relevance 0.74
The expression of ASIC1a and ASIC1b was increased in the ipsilateral DRGs, whereas the ASIC3 and TRPV1 expression was not changed.
Positive_regulation (increased) of Gene_expression (expression) of ASIC1a in DRGs associated with ganglion cysts
5) Confidence 0.25 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.15 Pain Relevance 0.74
Such a postulate raises the question of whether NG2 cells express the acid chemsensor ASIC and if so, what are their functional properties and subunit composition?
Positive_regulation (raises) of Spec (whether) Gene_expression (express) of ASIC associated with asic
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.83 Pain Relevance 0.34
In addition, RT-PCR and western blot analysis showed the preconditioning followed by an ischemic event significantly increased the ASIC 2a mRNA and protein expression when compared to a single ischemic insult (p < 0.01, Figures 3, 4).
Positive_regulation (increased) of Gene_expression (expression) of ASIC associated with asic
7) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.92 Pain Relevance 0.53
Our results show that ASIC 2a expression increases in the hippocampus after global ischemia, and that ischemic preconditioning can further increase ASIC 2a expression.


Positive_regulation (increase) of Gene_expression (expression) of ASIC in hippocampus associated with ischemia, hippocampus and asic
8) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.84 Pain Relevance 0.77
Preconditioning before the ischemic event significantly increased expression of the ASIC 2a protein compared to ischemia alone (p < 0.01 at 72 h, p < 0.05 at 12 h and 24 h, Figure 4).
Positive_regulation (increased) of Gene_expression (expression) of ASIC associated with ischemia and asic
9) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.66 Pain Relevance 0.61
The expression of ASIC 2a protein in PC + Isch group increased over time and was maximal at 72 h.


Positive_regulation (increased) of Gene_expression (expression) of ASIC associated with asic
10) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.69 Pain Relevance 0.60
Our results show that ASIC 2a expression increases in the hippocampus after global ischemia, and that ischemic preconditioning can further increase ASIC 2a expression.


Positive_regulation (increases) of Gene_expression (expression) of ASIC in hippocampus associated with ischemia, hippocampus and asic
11) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.80 Pain Relevance 0.74
RT-PCR and western blot analysis showed that preconditioning prior to an ischemic insult significantly increased ASIC 2a mRNA and protein expression in comparison to the ischemic insult alone (p < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of ASIC associated with asic
12) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2820994 Disease Relevance 0.67 Pain Relevance 0.34
The increase in ASIC 2a mRNA expression in the hippocampal CA1 region in the preconditioned group (PC + Isch) was maximal at 24 h and persisted even at 72 h.


Positive_regulation (increase) of Gene_expression (expression) of ASIC associated with asic
13) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.60 Pain Relevance 0.58

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