INT120656

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.60
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
Urine 1
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 91.88 High High
alcohol 1 74.88 Quite High
Central nervous system 1 70.56 Quite High
Inflammation 16 32.00 Quite Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 18 100.00 Very High Very High Very High
Variegate Porphyria 42 94.52 High High
Neuropathy 1 92.92 High High
Abdominal Pain 2 91.88 High High
Obesity 4 90.56 High High
Infection 1 77.80 Quite High
Overnutrition 1 77.32 Quite High
Colon Cancer 3 73.20 Quite High
Lead Poisoning 1 71.60 Quite High
Fever 1 68.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
which both PPARs and the UPS are implicated is the Wnt pathway.
Localization (implicated) of UPS
1) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.25 Pain Relevance 0
Urine ALA and PBG are also measured for confirmation of an acute attack and for exclusion of other forms of Porphyria.
Localization (measured) of PBG in Urine associated with porphyria
2) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2467414 Disease Relevance 1.53 Pain Relevance 0.14
Urinary excretion of porphobilinogen (PBG) and uroporphyrin was only slightly increased.
Localization (excretion) of porphobilinogen associated with porphyria
3) Confidence 0.01 Published 2004 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 15303011 Disease Relevance 0.82 Pain Relevance 0.09

General Comments

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