INT12066

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 3.06
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
striatum 3
T-cell 3
arcuate nucleus 2
median eminence 2
microglia 1
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 47 100.00 Very High Very High Very High
monoamine 5 100.00 Very High Very High Very High
Calcium channel 2 99.60 Very High Very High Very High
dexamethasone 9 99.58 Very High Very High Very High
narcan 11 99.28 Very High Very High Very High
cytokine 50 98.00 Very High Very High Very High
tetrodotoxin 10 96.56 Very High Very High Very High
anesthesia 5 96.56 Very High Very High Very High
Neurotransmitter 14 96.44 Very High Very High Very High
Inflammation 97 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 105 95.24 Very High Very High Very High
Injury 31 94.00 High High
Stress 18 91.60 High High
Infection 80 90.88 High High
Euthyroid Sick Syndrome 1 89.68 High High
Intracranial Hypertension 1 87.48 High High
Myocardial Infarction 1 86.40 High High
Sleep Disorders 76 85.56 High High
Sepsis 14 83.12 Quite High
Reperfusion Injury 292 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-2 mRNA (1.5 kb size), endogenous IL-2 and IL-2 receptors were found to be distributed throughout the rat striatum in moderate densities.
Localization (distributed) of IL-2 in striatum
1) Confidence 0.75 Published 1992 Journal Neuroreport Section Abstract Doc Link 1623167 Disease Relevance 0 Pain Relevance 0.11
IL-2 mRNA (1.5 kb size), endogenous IL-2 and IL-2 receptors were found to be distributed throughout the rat striatum in moderate densities.
Localization (distributed) of IL-2 in striatum
2) Confidence 0.75 Published 1992 Journal Neuroreport Section Abstract Doc Link 1623167 Disease Relevance 0 Pain Relevance 0.11
IL-2 mRNA (1.5 kb size), endogenous IL-2 and IL-2 receptors were found to be distributed throughout the rat striatum in moderate densities.
Localization (distributed) of IL-2 in striatum
3) Confidence 0.75 Published 1992 Journal Neuroreport Section Abstract Doc Link 1623167 Disease Relevance 0 Pain Relevance 0.11
In the hypothalamus, the highest levels of endogenous IL-2 and IL-2 receptors were localized to the median eminence and arcuate nucleus.
Localization (localized) of IL-2 in median eminence
4) Confidence 0.75 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477053 Disease Relevance 0 Pain Relevance 0.46
In the hypothalamus, the highest levels of endogenous IL-2 and IL-2 receptors were localized to the median eminence and arcuate nucleus.
Localization (localized) of IL-2 in median eminence
5) Confidence 0.75 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477053 Disease Relevance 0 Pain Relevance 0.46
Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus.
Localization (release) of Interleukin-2 in hypothalamus associated with opioid and monoamine
6) Confidence 0.71 Published 1993 Journal Neuroreport Section Title Doc Link 8477053 Disease Relevance 0 Pain Relevance 0.51
Since high-potassium-induced release of CRF is probably due to opening of voltage-dependent calcium channels, it is likely that IL-2 is releasing CRF by this mechanism.
Localization (releasing) of IL-2 associated with calcium channel
7) Confidence 0.68 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.17 Pain Relevance 0.32
Effects of luteinizing-hormone-releasing hormone, alpha-melanocyte-stimulating hormone, naloxone, dexamethasone and indomethacin on interleukin-2-induced corticotropin-releasing factor release.
Localization (release) of interleukin-2-induced in melanocyte associated with narcan and dexamethasone
8) Confidence 0.60 Published 1995 Journal Neuroimmunomodulation Section Title Doc Link 8646567 Disease Relevance 0.13 Pain Relevance 0.18
In the hypothalamus, the highest levels of endogenous IL-2 and IL-2 receptors were localized to the median eminence and arcuate nucleus.
Localization (localized) of IL-2 in arcuate nucleus
9) Confidence 0.26 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477053 Disease Relevance 0 Pain Relevance 0.46
In the hypothalamus, the highest levels of endogenous IL-2 and IL-2 receptors were localized to the median eminence and arcuate nucleus.
Localization (localized) of IL-2 in arcuate nucleus
10) Confidence 0.26 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477053 Disease Relevance 0 Pain Relevance 0.46
In contrast, mitogen-induced lymphocyte proliferation, IL-2, and IL-4 secretion were not depressed.
Localization (secretion) of IL-2 in lymphocyte
11) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.65 Pain Relevance 0.36
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Localization (release) of IL-2 in microglia
12) Confidence 0.10 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.66
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Localization (secretion) of interleukin-2 in T-cell associated with injury
13) Confidence 0.10 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.49 Pain Relevance 0.11
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Localization (secretion) of IL-2 in T-cell associated with injury
14) Confidence 0.10 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Localization (secretion) of IL-2 in T-cell associated with injury
15) Confidence 0.09 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11
IL-1 has been shown to suppress TSH secretion [59], whereas IL-2 has been shown to stimulate the pituitary–thyroid axis [65].
Localization (secretion) of IL-2 in thyroid
16) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.62 Pain Relevance 0.18

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