INT120676

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.79
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 1
brain 1
Tm2d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 36 100.00 Very High Very High Very High
Disease 4 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices.
Localization (release) of beta-amyloid associated with alzheimer's dementia
1) Confidence 0.28 Published 2004 Journal Phytother Res Section Title Doc Link 15305316 Disease Relevance 0.71 Pain Relevance 0.06
In contrast, addition of the same concentration range of ginkgolide A (GKA, 0.01-10 micro M) had no effect on beta-amyloid-inhibited ACh release.
Localization (release) of beta-amyloid associated with alzheimer's dementia
2) Confidence 0.28 Published 2004 Journal Phytother Res Section Abstract Doc Link 15305316 Disease Relevance 0.68 Pain Relevance 0.09
The reversal of the beta-amyloid-inhibited ACh release by GKB (1 micro M) was not blocked by tetrodotoxin (1 micro M) indicating a direct interaction of GKB on the cholinergic nerve terminals.
Localization (release) of beta-amyloid in nerve associated with tetrodotoxin and alzheimer's dementia
3) Confidence 0.28 Published 2004 Journal Phytother Res Section Abstract Doc Link 15305316 Disease Relevance 0.74 Pain Relevance 0.10
As Ginkgo has been shown to improve age-related memory de fi cits and beta-amyloid-related peptides have been suggested to play a signi fi cant role in memory degeneration in Alzheimer's disease, the present study was carried out to examine the effect of two major ginkgolides, A and B, on beta-amyloid peptide-modulated acetylcholine (ACh) release from hippocampal brain slices.
Localization (release) of beta-amyloid in brain associated with alzheimer's dementia and disease
4) Confidence 0.28 Published 2004 Journal Phytother Res Section Abstract Doc Link 15305316 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

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