INT120693

Context Info Confidence 0.50 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 8.22 Pain Relevance 0.79

extracellular region (MEPE) proteinaceous extracellular matrix (MEPE)

Anatomy Link Frequency spindle cells 1 neural crest 1 muscle 1 MEPE (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 8 97.20 cytokine 3 91.12 pain flank 2 89.96 Pain 9 85.44 Hypoesthesia 1 78.04 imagery 18 77.36 Spinal cord 2 75.44 cva 4 21.08 Sciatic nerve 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Cancer 87 100.00 Disease 6 100.00 Skin Cancer 12 99.46 Metastasis 54 99.08 Nerve Sheath Neoplasms 17 98.90 Myeloid Leukemia 3 97.64 INFLAMMATION 4 97.20 Malignant Neoplastic Disease 11 97.00 Renal Cell Carcinoma 35 96.88 Necrosis 3 96.16

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin.

Positive_regulation (negative) of HMB-45

1) Confidence 0.50 Published 2004 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15306940 Disease Relevance 0.90 Pain Relevance 0.15

The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.

Positive_regulation (positive) of HMB-45 associated with cancer

2) Confidence 0.40 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17493897 Disease Relevance 1.49 Pain Relevance 0.09

Both CCSTA and malignant melanoma are immunohistochemically positive for S-100 protein (a marker for tumors derived from neural crest) and HMB-45 (a marker identifying tumors associated with melanoma) [18] suggesting that these tumors have a close relationship.

Positive_regulation (positive) of HMB-45 in neural crest associated with cancer and skin cancer

3) Confidence 0.06 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 1.62 Pain Relevance 0

Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.

Positive_regulation (negative) of HMB-45 associated with cancer

4) Confidence 0.05 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.34 Pain Relevance 0.26

Immunoperoxidase testing was positive for CD10 and vimentin and negative for gross cystic disease fluid protein (GCDFP), S-100, HMB-45, muscle-specific antigen, and desmin, supporting the diagnosis of metastatic RCC (Figure 3).

Positive_regulation (positive) of HMB-45 in muscle associated with renal cell carcinoma and disease

5) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566576 Disease Relevance 0.80 Pain Relevance 0

The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.

Positive_regulation (positive) of HMB45 in spindle cells

6) Confidence 0.02 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.86 Pain Relevance 0.21

In the case presented here, the tumor was further characterized as a melanocytic MPNST because the melanin-containing cells were found to be positive for HMB45.

Positive_regulation (positive) of HMB45 associated with nerve sheath neoplasms and cancer

7) Confidence 0.02 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1780055 Disease Relevance 1.21 Pain Relevance 0.08

General Comments

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