INT120693

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 8.22
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MEPE) proteinaceous extracellular matrix (MEPE)
Anatomy Link Frequency
spindle cells 1
neural crest 1
muscle 1
MEPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 97.20 Very High Very High Very High
cytokine 3 91.12 High High
pain flank 2 89.96 High High
Pain 9 85.44 High High
Hypoesthesia 1 78.04 Quite High
imagery 18 77.36 Quite High
Spinal cord 2 75.44 Quite High
cva 4 21.08 Low Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 87 100.00 Very High Very High Very High
Disease 6 100.00 Very High Very High Very High
Skin Cancer 12 99.46 Very High Very High Very High
Metastasis 54 99.08 Very High Very High Very High
Nerve Sheath Neoplasms 17 98.90 Very High Very High Very High
Myeloid Leukemia 3 97.64 Very High Very High Very High
INFLAMMATION 4 97.20 Very High Very High Very High
Malignant Neoplastic Disease 11 97.00 Very High Very High Very High
Renal Cell Carcinoma 35 96.88 Very High Very High Very High
Necrosis 3 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin.
Positive_regulation (negative) of HMB-45
1) Confidence 0.50 Published 2004 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15306940 Disease Relevance 0.90 Pain Relevance 0.15
The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.
Positive_regulation (positive) of HMB-45 associated with cancer
2) Confidence 0.40 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17493897 Disease Relevance 1.49 Pain Relevance 0.09
Both CCSTA and malignant melanoma are immunohistochemically positive for S-100 protein (a marker for tumors derived from neural crest) and HMB-45 (a marker identifying tumors associated with melanoma) [18] suggesting that these tumors have a close relationship.
Positive_regulation (positive) of HMB-45 in neural crest associated with cancer and skin cancer
3) Confidence 0.06 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 1.62 Pain Relevance 0
Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.
Positive_regulation (negative) of HMB-45 associated with cancer
4) Confidence 0.05 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.34 Pain Relevance 0.26
Immunoperoxidase testing was positive for CD10 and vimentin and negative for gross cystic disease fluid protein (GCDFP), S-100, HMB-45, muscle-specific antigen, and desmin, supporting the diagnosis of metastatic RCC (Figure 3).
Positive_regulation (positive) of HMB-45 in muscle associated with renal cell carcinoma and disease
5) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566576 Disease Relevance 0.80 Pain Relevance 0
The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.
Positive_regulation (positive) of HMB45 in spindle cells
6) Confidence 0.02 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.86 Pain Relevance 0.21
In the case presented here, the tumor was further characterized as a melanocytic MPNST because the melanin-containing cells were found to be positive for HMB45.


Positive_regulation (positive) of HMB45 associated with nerve sheath neoplasms and cancer
7) Confidence 0.02 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1780055 Disease Relevance 1.21 Pain Relevance 0.08

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