INT120694

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.08
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
Anatomy Link Frequency
lungs 2
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 88.80 High High
Calcium channel 3 63.68 Quite High
depression 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
TRP channel 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 20 99.62 Very High Very High Very High
Lung Injury 1 99.54 Very High Very High Very High
Heart Rate Under Development 4 98.58 Very High Very High Very High
Death 1 91.88 High High
Targeted Disruption 2 91.12 High High
Abdominal Pain 2 88.80 High High
Pressure And Volume Under Development 9 69.16 Quite High
Diarrhoea 4 67.96 Quite High
Overdose 1 61.60 Quite High
Cystic Fibrosis 1 5.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UC was associated with substantial decreases in the expression of the ENaC beta- and gamma-subunit proteins and mRNAs, whereas the decrease in ENaC alpha-subunit protein detected by immunolocalization was less marked.
Negative_regulation (decreases) of Gene_expression (expression) of ENaC associated with inflammatory bowel disease
1) Confidence 0.32 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.85 Pain Relevance 0.09
Taken together, these results show that UC results mainly in decreased expression of the apical ENaC beta- and gamma-subunits, as well as the basolateral Na+, K+-ATPase alpha1- and beta1-isoforms.
Negative_regulation (decreased) of Gene_expression (expression) of ENaC associated with inflammatory bowel disease
2) Confidence 0.23 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.59 Pain Relevance 0.07
In adult lungs, high attitude pulmonary edema and pathogen-challenged edematous lung injuries have been linked to a reduction of both ENaC expression and activity levels [16,17].
Negative_regulation (reduction) of Gene_expression (expression) of ENaC in lungs associated with lung injury and heart rate under development
3) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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