INT120696

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 5.46
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
Anatomy Link Frequency
colon 1
lungs 1
oocytes 1
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 4 99.48 Very High Very High Very High
dexamethasone 5 99.06 Very High Very High Very High
cytokine 84 95.08 Very High Very High Very High
Inflammation 136 94.68 High High
Inflammatory mediators 80 79.64 Quite High
agonist 25 75.92 Quite High
depression 15 65.00 Quite High
Calcium channel 15 62.96 Quite High
fibrosis 29 62.80 Quite High
Dopamine 4 53.48 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 56 99.84 Very High Very High Very High
Abdominal Pain 4 99.48 Very High Very High Very High
Lung Injury 5 99.18 Very High Very High Very High
Heart Rate Under Development 64 98.22 Very High Very High Very High
INFLAMMATION 224 94.68 High High
Diarrhoea 40 92.16 High High
Death 5 91.16 High High
Disease 40 90.64 High High
Targeted Disruption 10 90.40 High High
Infection 4 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results show that UC results mainly in decreased expression of the apical ENaC beta- and gamma-subunits, as well as the basolateral Na+, K+-ATPase alpha1- and beta1-isoforms.
Gene_expression (expression) of ENaC associated with inflammatory bowel disease
1) Confidence 0.43 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.59 Pain Relevance 0.07
UC was associated with substantial decreases in the expression of the ENaC beta- and gamma-subunit proteins and mRNAs, whereas the decrease in ENaC alpha-subunit protein detected by immunolocalization was less marked.
Gene_expression (expression) of ENaC associated with inflammatory bowel disease
2) Confidence 0.43 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.85 Pain Relevance 0.09
ENaC subunit expression was studied by immunohistochemistry, western blot analysis, and in situ hybridization, and Na+, K+-ATPase isoform expression was studied by immunohistochemistry, western blotting, and northern blot analysis.
Gene_expression (expression) of ENaC
3) Confidence 0.37 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.82 Pain Relevance 0.10
The effect of UC on the expression of apical Na+ channels (ENaC) and basolateral Na+, K+-ATPase, the critical determinants of electrogenic Na+ transport, was therefore investigated in this study.
Gene_expression (expression) of ENaC associated with inflammatory bowel disease
4) Confidence 0.37 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.77 Pain Relevance 0.08
Dexamethasone (250 nM, Sigma) was supplemented to stimulate ENaC expression.
Gene_expression (expression) of ENaC associated with dexamethasone
5) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.19 Pain Relevance 0.05
In adult lungs, high attitude pulmonary edema and pathogen-challenged edematous lung injuries have been linked to a reduction of both ENaC expression and activity levels [16,17].
Gene_expression (expression) of ENaC in lungs associated with lung injury and heart rate under development
6) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.63 Pain Relevance 0.03
KCa channels, until recently known as K Ca3.1 and BKCa, are functionally detected in ENaC-expressing primary airway and ATII cells [24-26].
Gene_expression (expressing) of ENaC
7) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.32 Pain Relevance 0.03
The direct inhibitory effects of Ca2+ ions on ENaC in vitro [60,61] were, perhaps, overwhelmed by the stimulatory effects of Ca2+ downstream signals on ENaC and other transporters in these cell models and in vivo studies.
Gene_expression (ions) of ENaC
8) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.04
Another group reported that the expression of beta-and gamma-subunits of ENaC was inhibited by both TNF and IL-1 beta in rat distal colon.
Gene_expression (expression) of ENaC in colon
9) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.03
IFN gamma had no effect on ENaC expression in this study [90].
Gene_expression (expression) of ENaC
10) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.03
ENaC-expressing oocytes completely abolished verapamil-induced inhibition.
Gene_expression (expressing) of ENaC in oocytes
11) Confidence 0.05 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2889873 Disease Relevance 0.07 Pain Relevance 0.06
In an ex vivo human colonic mucosa plus submucosa preparation of patients with ulcerative colitis aldosterone was unable to stimulate electrogenic sodium transport in the Ussing chamber or ENaC mRNA levels and protein expression [See figure 3].
Gene_expression (expression) of ENaC associated with inflammatory bowel disease
12) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.16 Pain Relevance 0.04
This down regulation affects not only protein function but also gene expression of ENaC and/or Na/K ATPase.
Gene_expression (expression) of ENaC
13) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.90 Pain Relevance 0.38

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