INT120697

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 3.53
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
Anatomy Link Frequency
lungs 2
apical cell 1
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 22 97.60 Very High Very High Very High
bradykinin 30 97.40 Very High Very High Very High
cytokine 63 92.24 High High
Inflammation 102 88.84 High High
antagonist 13 85.52 High High
abdominal pain 1 84.96 Quite High
Inflammatory mediators 60 77.68 Quite High
Calcium channel 18 76.60 Quite High
Kinase C 6 66.40 Quite High
sodium channel 27 58.12 Quite High
Disease Link Frequency Relevance Heat
Lung Injury 6 99.54 Very High Very High Very High
Natriuresis 6 98.60 Very High Very High Very High
Heart Rate Under Development 57 98.58 Very High Very High Very High
Inflammatory Bowel Disease 22 97.42 Very High Very High Very High
Targeted Disruption 12 93.76 High High
Death 6 92.00 High High
INFLAMMATION 168 88.84 High High
Abdominal Pain 1 84.96 Quite High
Disease 28 84.80 Quite High
Pressure And Volume Under Development 66 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UC was associated with substantial decreases in the expression of the ENaC beta- and gamma-subunit proteins and mRNAs, whereas the decrease in ENaC alpha-subunit protein detected by immunolocalization was less marked.
Negative_regulation (decrease) of ENaC alpha-subunit associated with inflammatory bowel disease
1) Confidence 0.32 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.84 Pain Relevance 0.08
The chemical agents acting on ENaC are, however, largely unknown, except for amiloride and benzamil as ENaC inhibitors.
Neg (except) Negative_regulation (inhibitors) of ENaC
2) Confidence 0.30 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15308635 Disease Relevance 0 Pain Relevance 0.09
K+ channel openers restore the suppressed ENaC activity in vitro to a significant extent.
Negative_regulation (suppressed) of ENaC
3) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.03
We thereby attempted to determine the individual contribution of each functional subtype of K+ channels (KV, KCa3.1 and KATP) to verapamil-inhibited ENaC activity.
Negative_regulation (inhibited) of ENaC
4) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0
An average of 38.2 ± 5.5% ENaC currents was reduced by verapamil (P < 0.05, n = 4, Fig. 9C), suggesting that verapamil may also directly reduce native ENaC channel activity in H441 cells.
Spec (may) Negative_regulation (reduce) of ENaC
5) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0
Increasing amounts of etiological evidence suggests that genetic and pathologic ENaC deficiency gives rise to the genesis of flooding airspaces [13,14].
Negative_regulation (deficiency) of ENaC
6) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.65 Pain Relevance 0.04
In adult lungs, high attitude pulmonary edema and pathogen-challenged edematous lung injuries have been linked to a reduction of both ENaC expression and activity levels [16,17].
Negative_regulation (reduction) of ENaC in lungs associated with lung injury and heart rate under development
7) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.64 Pain Relevance 0.03
Interruption of K+ ion recycling may be a critical mechanism for CCB-induced inhibition of ENaC activity (Fig. 11).
Negative_regulation (inhibition) of ENaC
8) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.08 Pain Relevance 0
There is evidence that in alveolar epithelial cells as opposed to upper airways epithelia a reduction in CFTR function is linked to a reduction in sodium transport through ENaC, which may contribute to the reduced lung liquid clearance observed in pulmonary edema.
Negative_regulation (reduction) of ENaC in lung associated with heart rate under development
9) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.36 Pain Relevance 0.03
This effect is mediated by inhibition of ENaC and Na/K ATPase activity possibly mediated by an increase in intracellular calcium and/or pH.
Negative_regulation (inhibition) of ENaC
10) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.10 Pain Relevance 0.30
PGE2 supports the inhibition of ENaC at the apical cell membrane by inducing a concomitant reduction in the activity or expression of the Na/K ATPase at the basolateral membrane.
Negative_regulation (inhibition) of ENaC in apical cell
11) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.86 Pain Relevance 0.31

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