INT120708

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.27
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc4a8)
Anatomy Link Frequency
duodenum 4
sensory neuron 2
afferent neurons 2
Slc4a8 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 21 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Luminal acidification increased the mucosal level of PGE2 as well as 6-keto-PGF1alpha, yet stimulated HCO3- secretion in both WT and IP (-/-) mice, in an indomethacin-inhibitable and sensory neuron-dependent manners.
Positive_regulation (increased) of Localization (secretion) of HCO3 in sensory neuron
1) Confidence 0.40 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0.08 Pain Relevance 0
Although duodenal HCO3- secretion induced by both acid and capsaicin depends on afferent neurons, it seems that the mode of interaction with the afferent neurons differs regarding dependency on the PGI2/IP receptors.


Positive_regulation (induced) of Localization (secretion) of HCO3 in afferent neurons
2) Confidence 0.27 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0 Pain Relevance 0
RESULTS: PGE2 stimulated HCO3- secretion in both WT and IP (-/-) mice, while cicaprost increased it in WT but not IP (-/-) mice.
Positive_regulation (stimulated) of Localization (secretion) of HCO3
3) Confidence 0.27 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: The presence of IP receptors is not essential for acid-induced HCO3- secretion and mucosal defense against acid injury in the duodenum, although activation of IP receptors results in stimulation of HCO3- secretion.
Positive_regulation (stimulation) of Localization (secretion) of HCO3 in duodenum
4) Confidence 0.27 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The presence of IP receptors is not essential for acid-induced HCO3- secretion and mucosal defense against acid injury in the duodenum, although activation of IP receptors results in stimulation of HCO3- secretion.
Neg (not) Positive_regulation (essential) of Localization (secretion) of HCO3 in duodenum
5) Confidence 0.27 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0.05 Pain Relevance 0
No role for prostacyclin IP receptors in duodenal HCO3- secretion induced by mucosal acidification in mice--comparison with capsaicin-induced response.
Positive_regulation (induced) of Localization (secretion) of HCO3 associated with qutenza
6) Confidence 0.27 Published 2004 Journal Digestion Section Title Doc Link 15308871 Disease Relevance 0 Pain Relevance 0.29
Capsaicin increased duodenal HCO3- secretion in WT mice, in an indomethacin-sensitive manner, yet no such response was observed in the animals lacking IP receptors.
Positive_regulation (increased) of Localization (secretion) of HCO3
7) Confidence 0.27 Published 2004 Journal Digestion Section Body Doc Link 15308871 Disease Relevance 0.06 Pain Relevance 0

General Comments

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