INT120710

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.72
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
PGE2 1
body 1
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 153 99.76 Very High Very High Very High
Inflammation 61 99.04 Very High Very High Very High
aspirin 11 97.72 Very High Very High Very High
COX-2 inhibitor 21 95.56 Very High Very High Very High
Inflammatory mediators 9 95.08 Very High Very High Very High
Pain 22 93.00 High High
Hyperalgesia 9 92.24 High High
IPN 12 89.88 High High
Spontaneous pain 3 87.72 High High
Thermal hyperalgesia 45 74.88 Quite High
Disease Link Frequency Relevance Heat
Nociception 33 99.20 Very High Very High Very High
INFLAMMATION 76 99.04 Very High Very High Very High
Pain 25 93.00 High High
Hyperalgesia 54 92.24 High High
Inflammatory Pain 12 89.88 High High
Thrombosis 1 89.36 High High
Thrombosis Related Under Development 1 84.08 Quite High
Injury 10 76.08 Quite High
Myocardial Infarction 7 66.80 Quite High
Myocardial Stunning 1 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No role for prostacyclin IP receptors in duodenal HCO3- secretion induced by mucosal acidification in mice--comparison with capsaicin-induced response.
Localization (secretion) of prostacyclin associated with qutenza
1) Confidence 0.54 Published 2004 Journal Digestion Section Title Doc Link 15308871 Disease Relevance 0 Pain Relevance 0.29
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia.

Localization (Sensitization) of IP in PGE2 associated with nociception, pain, hyperalgesia and inflammatory mediators
2) Confidence 0.30 Published 2005 Journal Mol Pain Section Title Doc Link PMC1074353 Disease Relevance 0.70 Pain Relevance 0.51
In the presence of PGE2 or PGI2, the temperature threshold for TRPV1 activation was reduced below 35°C, so that temperatures near body temperature are sufficient to activate TRPV1.
Localization (presence) of PGI2 in body
3) Confidence 0.26 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.68 Pain Relevance 0.50
It is not well known how much PGE2 or PGI2 is released locally at the site of inflammation.
Localization (released) of PGI2 associated with inflammation
4) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.78 Pain Relevance 0.46
The study of Hennan et al. also suggests the important role of COX-2-derived PGI2, and it raises concerns regarding an increased risk of acute vascular thrombotic events in patients receiving COX-2 inhibitors [8].
Localization (role) of PGI2 associated with cox-2 inhibitor
5) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.57 Pain Relevance 0.25

General Comments

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