INT120715

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 5.53
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr)
enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)
Anatomy Link Frequency
astrocytes 2
hearts 2
margin 1
Egfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 6 99.98 Very High Very High Very High
metalloproteinase 20 99.66 Very High Very High Very High
bradykinin 17 99.50 Very High Very High Very High
COX2 2 99.20 Very High Very High Very High
ischemia 12 98.82 Very High Very High Very High
MU agonist 4 97.44 Very High Very High Very High
Opioid 4 97.24 Very High Very High Very High
COX-2 inhibitor 4 93.44 High High
Spinal cord 8 91.48 High High
Enkephalin 4 90.80 High High
Disease Link Frequency Relevance Heat
Ulcers 101 99.44 Very High Very High Very High
Cv Unclassified Under Development 12 98.82 Very High Very High Very High
Myocardial Infarction 4 96.32 Very High Very High Very High
INFLAMMATION 32 95.88 Very High Very High Very High
Colon Cancer 18 94.60 High High
Infarction 4 92.24 High High
Frailty 8 91.76 High High
Cicatrix 6 91.60 High High
Lymphatic System Cancer 1 91.52 High High
Disease 4 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8.
Positive_regulation (transactivation) of epidermal growth factor receptor associated with metalloproteinase and bradykinin
1) Confidence 0.68 Published 2009 Journal Acta Physiol (Oxf) Section Title Doc Link 19583703 Disease Relevance 0.10 Pain Relevance 0.46
In rabbit, this protection leads to phosphorylation of the pro-survival kinases Akt and extracellular signal-regulated kinase (ERK) and is dependent on transactivation of the epidermal growth factor receptor (EGFR).
Positive_regulation (transactivation) of EGFR
2) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.32 Pain Relevance 0.40
In rabbit, this protection leads to phosphorylation of the pro-survival kinases Akt and extracellular signal-regulated kinase (ERK) and is dependent on transactivation of the epidermal growth factor receptor (EGFR).
Positive_regulation (transactivation) of epidermal growth factor receptor
3) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.32 Pain Relevance 0.40
Thus the delta-opioid agonist DADLE protects rabbit hearts at reperfusion through activation of the pro-survival kinases Akt and ERK and is dependent on the transactivation of the EGFR.
Positive_regulation (transactivation) of EGFR in hearts associated with mu agonist
4) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.13 Pain Relevance 0.27
to block ligand-dependant activation of EGFR, and induce receptor internalization and consequent downregulation19.
Positive_regulation (activation) of EGFR
5) Confidence 0.64 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.89 Pain Relevance 0
Epidermal growth factor receptor (EGFR) activation triggers astrocytes into becoming reactive astrocytes, and EGFR ligands stimulate the secretion of CSPGs as well as the formation of cribriform astrocyte arrangements that contribute to the formation of glial scars.
Positive_regulation (activation) of EGFR in astrocytes associated with cicatrix
6) Confidence 0.50 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17567803 Disease Relevance 0.32 Pain Relevance 0.11
Epidermal growth factor receptor (EGFR) activation triggers astrocytes into becoming reactive astrocytes, and EGFR ligands stimulate the secretion of CSPGs as well as the formation of cribriform astrocyte arrangements that contribute to the formation of glial scars.
Positive_regulation (activation) of Epidermal growth factor receptor in astrocytes associated with cicatrix
7) Confidence 0.50 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17567803 Disease Relevance 0.32 Pain Relevance 0.11
CONCLUSION: These results indicate that BK at reperfusion triggers its protective signalling pathway through MMP-8-dependent transactivation of the EGFR.


Positive_regulation (transactivation) of EGFR
8) Confidence 0.49 Published 2009 Journal Acta Physiol (Oxf) Section Body Doc Link 19583703 Disease Relevance 0 Pain Relevance 0
Muscarinic and opioid G-protein-coupled receptors are equally protective and have been shown to couple through a matrix metalloproteinase (MMP)-dependent transactivation of the epidermal growth factor receptor (EGFR).
Positive_regulation (transactivation) of epidermal growth factor receptor associated with metalloproteinase and opioid
9) Confidence 0.49 Published 2009 Journal Acta Physiol (Oxf) Section Abstract Doc Link 19583703 Disease Relevance 0.09 Pain Relevance 0.46
Muscarinic and opioid G-protein-coupled receptors are equally protective and have been shown to couple through a matrix metalloproteinase (MMP)-dependent transactivation of the epidermal growth factor receptor (EGFR).
Positive_regulation (transactivation) of EGFR associated with metalloproteinase and opioid
10) Confidence 0.49 Published 2009 Journal Acta Physiol (Oxf) Section Abstract Doc Link 19583703 Disease Relevance 0.09 Pain Relevance 0.46
We therefore tested whether DADLE at reperfusion could protect isolated rabbit hearts subjected to 30 min of regional ischemia and 120 min of reperfusion and whether this protection is dependent on Akt, ERK, and EGFR.
Spec (whether) Positive_regulation (dependent) of EGFR in hearts associated with ischemia
11) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.33 Pain Relevance 0.40
Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.
Positive_regulation (modulates) of epidermal growth factor receptor associated with cox2
12) Confidence 0.47 Published 2007 Journal Clin. Cancer Res. Section Title Doc Link 17908994 Disease Relevance 0.19 Pain Relevance 0.19
EGFR is activated by EGF-like ligands, including EGF, transforming growth factor alpha (TGF-?)
Positive_regulation (activated) of EGFR
13) Confidence 0.43 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.05 Pain Relevance 0
All NSAIDs enhanced transforming growth factor alpha and epidermal growth factor receptor immunoreactivity around the acid-induced lesions.
Positive_regulation (enhanced) of epidermal growth factor receptor associated with cinod
14) Confidence 0.34 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15309881 Disease Relevance 0.05 Pain Relevance 0.32
Immunohistochemical studies demonstrated that cells lining dilated gastric glands at the ulcer margin display an enormous increase in expression of EGF, EGFR, and TNF-a at the initial stage (1–7 days) after ulcer induction [7, 13, 15].
Positive_regulation (increase) of EGFR in margin associated with ulcers
15) Confidence 0.31 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.09 Pain Relevance 0
In the case of receptor tyrosine kinases (RTKs), activation of the epidermal growth factor receptor inhibits M/KCNQ currents through the two distinct mechanisms of membrane PtdIns(4,5)P2 hydrolysis and tyrosine phosphorylation of the channel (Jia et al., 2007).
Positive_regulation (activation) of epidermal growth factor receptor
16) Confidence 0.17 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.08 Pain Relevance 0.12
Furthermore, L. rhamnosus GG up-regulated the phosphorylation level of epidermal growth factor receptor (EGF receptor) without altering the total EGF receptor expression.
Positive_regulation (up-regulated) of epidermal growth factor receptor
17) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.16 Pain Relevance 0.06

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