INT120717

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 50
Total Number 55
Disease Relevance 27.94
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
liver 18
hepatocytes 5
telomere 4
somatic cells 2
embryonic stem cells 2
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 421 99.92 Very High Very High Very High
Chronic pancreatitis 5 99.84 Very High Very High Very High
Kinase C 244 99.66 Very High Very High Very High
COX2 1 99.02 Very High Very High Very High
cINOD 10 97.32 Very High Very High Very High
COX-2 inhibitor 5 90.24 High High
chemokine 22 90.16 High High
cytokine 148 89.56 High High
Inflammatory response 8 88.48 High High
fibrosis 9 67.64 Quite High
Disease Link Frequency Relevance Heat
Hepatitis 639 100.00 Very High Very High Very High
INFLAMMATION 449 99.92 Very High Very High Very High
Cancer 491 99.86 Very High Very High Very High
Stomach Cancer 5 99.84 Very High Very High Very High
Pancreatitis 5 99.84 Very High Very High Very High
Hyperplasia 392 99.60 Very High Very High Very High
Pancreatic Cancer 33 99.58 Very High Very High Very High
Prostate Cancer 19 99.48 Very High Very High Very High
Chronic Hepatitis 105 99.42 Very High Very High Very High
Breast Cancer 17 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of pancreatic cancer to anticancer drugs up-regulates telomerase activity, and the increase in telomerase activity correlates with resistance to the drug-induced apoptosis.
Positive_regulation (up-regulates) of telomerase associated with pancreatic cancer and apoptosis
1) Confidence 0.63 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.81 Pain Relevance 0
Exposure of pancreatic cancer to anticancer drugs up-regulates telomerase activity, and the increase in telomerase activity correlates with resistance to the drug-induced apoptosis.
Positive_regulation (increase) of telomerase associated with pancreatic cancer and apoptosis
2) Confidence 0.55 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.81 Pain Relevance 0
Because the pancreatic juice has strong protease and RNase activity, addition of protease inhibitors and RNase inhibitors in the telomerase extraction buffer is necessary for the detection of telomerase activity in the pancreatic juice.
Positive_regulation (necessary) of telomerase
3) Confidence 0.46 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.84 Pain Relevance 0.09
Recent studies suggest that permissiveness of hepatocytes for telomerase activation might be impaired during chronic hepatitis.
Positive_regulation (activation) of telomerase in hepatocytes associated with chronic hepatitis
4) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.61 Pain Relevance 0.04
Telomerase activation
Positive_regulation (activation) of Telomerase
5) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.51 Pain Relevance 0
Pretreatment with these growth factors before partial hepatectomy increased telomerase activation in the remnant liver [17].
Positive_regulation (activation) of telomerase in liver
6) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.17 Pain Relevance 0
Interestingly, telomerase activation in embryonic stem cells is also associated with increased resistance to differentiation- and stress-induced apoptosis [10,11].
Positive_regulation (activation) of telomerase in embryonic stem cells associated with stress and apoptosis
7) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.42 Pain Relevance 0
Although, the mechanistic basis for some of these observations is not completely understood, we speculate that telomerase activation in liver regeneration might function as survival-promoting factor.
Positive_regulation (activation) of telomerase in liver
8) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.56 Pain Relevance 0.03
Telomerase, which ensures the unlimited proliferation by adding TTAGGG repeat at the end of the chromosome, is strongly activated at a very high incidence in a variety of malignant neoplasms including pancreatic cancer.
Positive_regulation (activated) of Telomerase associated with malignant neoplastic disease and pancreatic cancer
9) Confidence 0.42 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.65 Pain Relevance 0
A telomeric ladder was detected in 80% patients with carcinoma, whereas only 4.3% patients with adenoma and none with chronic pancreatitis showed positive telomerase activity.
Positive_regulation (positive) of telomerase associated with adenoma, carcinoma and chronic pancreatitis
10) Confidence 0.42 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.89 Pain Relevance 0.10
Three days after surgery, liver samples were collected and evaluated for mitotic activity, hepatitis score, and telomerase activity.
Positive_regulation (evaluated) of telomerase in liver associated with hepatitis
11) Confidence 0.32 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.33 Pain Relevance 0.04
To this regard, it has been shown that embryonic stem cells with high levels of telomerase activity accumulate lower concentrations of peroxides, implying greater resistance against oxidative stress [10].
Positive_regulation (levels) of telomerase in embryonic stem cells associated with stress
12) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.38 Pain Relevance 0
Since high levels of telomerase activity have also been detected in leucocytes, it has thus far remained an area of considerable controversy whether increased levels of telomerase activity in liver samples from patients with hepatitis result from telomerase activation in hepatocytes or from infiltrating leucocytes [32].
Spec (whether) Positive_regulation (levels) of telomerase in liver associated with hepatitis
13) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.35 Pain Relevance 0
Telomerase activation may constitute a mechanism to protect proliferating liver cells against telomere shortening and oxidative stress.


Positive_regulation (activation) of Telomerase in liver associated with stress
14) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.64 Pain Relevance 0.14
Our study was not designed to investigate the functional role of telomerase activation in liver regeneration.
Spec (investigate) Positive_regulation (activation) of telomerase in liver
15) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.53 Pain Relevance 0.03
Furthermore, as shown in primary mouse hepatocytes in vitro [17], major growth factors driving liver regeneration, namely hepatocyte growth factor and epidermal growth factor, are associated with telomerase activation.
Positive_regulation (activation) of telomerase in liver
16) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.18 Pain Relevance 0
Telomerase activation may constitute a mechanism to protect proliferating liver cells against telomere shortening and oxidative stress.



Positive_regulation (activation) of Telomerase in liver associated with stress
17) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Abstract Doc Link PMC1920532 Disease Relevance 0.68 Pain Relevance 0.04
In agreement with these studies and based on our findings, we suggest that telomerase activation in proliferating hepatocytes during liver regeneration represents, in analogy to what has been observed in human B lymphocytes, a protective mechanism to prevent chromosomal instability and early replicative exhaustion.
Positive_regulation (activation) of telomerase in B lymphocytes associated with chromosomal instability
18) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.27 Pain Relevance 0
Our data demonstrate telomerase activation in liver regeneration by compensatory hyperplasia in a large animal model with telomere biology comparable to humans.
Positive_regulation (activation) of telomerase in telomere associated with hyperplasia
19) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.68 Pain Relevance 0.07
In summary, telomerase activity was generally increased in treated animals (PH or PH/TIPS) in comparison to control animals (LT), but with much higher RTA values in animals with detectable mitotic hepatocytes.
Positive_regulation (increased) of telomerase in hepatocytes
20) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0 Pain Relevance 0

General Comments

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