INT120722

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 35
Total Number 40
Disease Relevance 19.26
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TYMP) cytosol (TYMP) small molecule metabolic process (TYMP)
Anatomy Link Frequency
blood cells 7
white blood cells 5
platelet 2
pancreas 2
plasma 1
TYMP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 29 96.24 Very High Very High Very High
Pain 20 93.60 High High
Hypoesthesia 8 92.24 High High
antagonist 24 89.08 High High
Serotonin 26 88.24 High High
abdominal pain 6 86.44 High High
dexamethasone 24 83.56 Quite High
Taxol 24 77.76 Quite High
fibrosis 9 76.40 Quite High
Somatostatin 16 73.88 Quite High
Disease Link Frequency Relevance Heat
Syndrome 112 100.00 Very High Very High Very High
Disease 67 100.00 Very High Very High Very High
Carcinoma 26 100.00 Very High Very High Very High
Adenocarcinoma 18 100.00 Very High Very High Very High
Cancer 766 99.82 Very High Very High Very High
Skin Cancer 19 99.72 Very High Very High Very High
Malignant Neoplastic Disease 60 99.66 Very High Very High Very High
Breast Cancer 138 99.04 Very High Very High Very High
Glaucoma 10 98.04 Very High Very High Very High
Oxidative Phosphorylation Disease 12 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thereafter, the expression of platelet derived endothelial cell growth factor/thymidine phosphorylase (PDECGF/TP) was measured by enzyme-linked immunosorbent assay.
Gene_expression (expression) of PDECGF in platelet
1) Confidence 0.75 Published 2004 Journal J. Urol. Section Body Doc Link 15311005 Disease Relevance 0.17 Pain Relevance 0
PDECGF/TP expression in patients with glomerulation was significantly higher than in symptomatic patients without glomerulation or asymptomatic patients (p < 0.001).
Gene_expression (expression) of PDECGF
2) Confidence 0.75 Published 2004 Journal J. Urol. Section Body Doc Link 15311005 Disease Relevance 0.13 Pain Relevance 0
The expression of thymidine phosphorylase was calculated as ng thymidine phosphorylase/mg protein of the cell lysate.
Gene_expression (expression) of thymidine phosphorylase
3) Confidence 0.74 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0 Pain Relevance 0
Beside a known elevated expression of thymidine phosphorylase within tumour cells and white blood cells [3], paclitaxel and other agents have the ability to induce this enzyme in the mouse model [4].
Gene_expression (expression) of thymidine phosphorylase in white blood cells associated with cancer
4) Confidence 0.74 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.55 Pain Relevance 0
To assess the expression of thymidine phosphorylase in blood cells, 8 ml blood were collected prior to therapy (day 1), at the end of the i.v. infusion, 24 h, 48 h, and 72 h later, as well as at days 8, 11, and 15.
Gene_expression (expression) of thymidine phosphorylase in blood
5) Confidence 0.74 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.37 Pain Relevance 0.26
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Gene_expression (expression) of thymidine phosphorylase in white blood cells
6) Confidence 0.74 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.36 Pain Relevance 0
The expression of thymidine phosphorylase was assessed in duplicates using an ELISA according to the manufacturer's instructions (Thymidine Phosphorylase ELISA; Roche, Mannheim, Germany).
Gene_expression (expression) of thymidine phosphorylase
7) Confidence 0.74 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.05 Pain Relevance 0
Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
Gene_expression (Expression) of thymidine phosphorylase associated with glaucoma and skin cancer
8) Confidence 0.69 Published 2005 Journal Pathol. Int. Section Title Doc Link 16143032 Disease Relevance 1.10 Pain Relevance 0.09
The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically.
Spec (examined) Gene_expression (expression) of thymidine phosphorylase
9) Confidence 0.69 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 16143032 Disease Relevance 1.12 Pain Relevance 0.08
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Gene_expression (expression) of thymidine phosphorylase in white blood cells
10) Confidence 0.65 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.43 Pain Relevance 0
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Gene_expression (expression) of thymidine phosphorylase in white blood cells
11) Confidence 0.65 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.42 Pain Relevance 0
Thereafter, the expression of platelet derived endothelial cell growth factor/thymidine phosphorylase (PDECGF/TP) was measured by enzyme-linked immunosorbent assay.
Gene_expression (expression) of thymidine phosphorylase in platelet
12) Confidence 0.58 Published 2004 Journal J. Urol. Section Body Doc Link 15311005 Disease Relevance 0.17 Pain Relevance 0
Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel

Background

Gene_expression (Expression) of thymidine phosphorylase in blood cells associated with breast cancer
13) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Title Doc Link PMC1939983 Disease Relevance 0.26 Pain Relevance 0
As consequence, the putative up-regulation of thymidine phosphorylase expression by paclitaxel would translate into modulatory benefit with negligible time delay in humans.
Gene_expression (expression) of thymidine phosphorylase
14) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.22 Pain Relevance 0
In parallel to serial assessment of thymidine phosphorylase expression, three characteristic data points of paclitaxel pharmacokinetics were used as a pharmacokinetic quality control parameter.


Gene_expression (expression) of thymidine phosphorylase
15) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.21 Pain Relevance 0
This congruence is indicative for a stable phenotype of TP expression in peripheral mononuclear blood cells, which is subject to little variation for at least eight weeks in humans.
Gene_expression (expression) of TP in blood cells
16) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0 Pain Relevance 0
In eight paclitaxel naive patients, the expression of thymidine phosphorylase in peripheral mononuclear blood cells temporarily decreased under infusion with paclitaxel equilibrating within 24 h to enzyme levels observed prior to therapy (Figure 1).
Gene_expression (expression) of thymidine phosphorylase in blood cells
17) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.07 Pain Relevance 0
In order to statistically describe significant courses in thymidine phosphorylase expression vs. time, a trend analysis was performed to test for slope deviations significantly different from zero.
Gene_expression (expression) of thymidine phosphorylase
18) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.07 Pain Relevance 0
Only then, the expression of thymidine phosphorylase increased moderately reaching levels similar to the baseline levels observed in paclitaxel naive patients.
Gene_expression (expression) of thymidine phosphorylase
19) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.05 Pain Relevance 0
The kinetics of thymidine phosphorylase expression were monitored in paclitaxel naive patients and compared with the observed concentrations after six administrations of paclitaxel (paired Wilcoxon test).
Gene_expression (expression) of thymidine phosphorylase
20) Confidence 0.58 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0 Pain Relevance 0

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