INT120723

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Calca) intracellular (Calca) cytoplasm (Calca)
lipid metabolic process (Trpv1) cytosol (Trpv1) extracellular space (Calca)
Anatomy Link Frequency
smooth muscle 3
sensory nerves 3
Trpv1 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
vanilloid receptor subtype 1 3 100.00 Very High Very High Very High
qutenza 9 99.10 Very High Very High Very High
antagonist 5 98.72 Very High Very High Very High
agonist 4 95.68 Very High Very High Very High
Inflammation 24 88.48 High High
Neuropeptide 14 87.44 High High
nociceptor 18 86.84 High High
Inflammatory mediators 12 75.12 Quite High
Cannabinoid 3 73.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 34 88.48 High High
Nociception 29 70.64 Quite High
Pain 57 56.76 Quite High
Arthritis 38 50.00 Quite Low
Poisoning 1 50.00 Quite Low
Arthralgia 19 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine.
Positive_regulation (activation) of TRPV1 Positive_regulation (mediated) of Localization (release) of CGRP associated with qutenza, antagonist and calcitonin gene-related peptide
1) Confidence 0.51 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 20162407 Disease Relevance 0.20 Pain Relevance 0.75
Rutaecarpine (Rut) can relax vascular smooth muscle via stimulation of calcitonin gene-related peptide (CGRP) release by activation of VR1.
Positive_regulation (activation) of VR1 in smooth muscle Positive_regulation (stimulation) of Localization (release) of calcitonin gene-related peptide in smooth muscle associated with vanilloid receptor subtype 1 and calcitonin gene-related peptide
2) Confidence 0.49 Published 2004 Journal J. Hypertens. Section Abstract Doc Link 15311112 Disease Relevance 0 Pain Relevance 0.46
Zygmunt and coworkers [88] deduced that anandamide activation of TRPV1 channels on sensory nerves causes the secondary release of CGRP.
Positive_regulation (activation) of TRPV1 in sensory nerves Positive_regulation (causes) of Localization (release) of CGRP in sensory nerves associated with calcitonin gene-related peptide
3) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794504 Disease Relevance 0.28 Pain Relevance 0.71

General Comments

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