INT120726

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 4
Total Number 17
Disease Relevance 0.51
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
retina 8
oocytes 4
osteoclast 2
neurons 2
serotonergic neurons 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 425 100.00 Very High Very High Very High
fluoxetine 133 98.84 Very High Very High Very High
sSRI 27 96.96 Very High Very High Very High
antidepressant 10 96.40 Very High Very High Very High
Raphe 73 95.36 Very High Very High Very High
depression 2 87.00 High High
monoamine 26 84.88 Quite High
Locus ceruleus 1 78.80 Quite High
primary somatosensory cortex 11 11.44 Low Low
Dopamine 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 132 88.36 High High
Affective Disorder 4 88.00 High High
Depression 3 87.00 High High
Vibrio Infection 11 53.68 Quite High
Targeted Disruption 11 25.88 Quite Low
Manic Depressive Disorder 2 21.04 Low Low
Adhesions 11 16.76 Low Low
Ganglion Cysts 33 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 19 5.00 Very Low Very Low Very Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Spec (investigated) Positive_regulation (enzyme) of Gene_expression (production) of SLC6A4 in oocytes
1) Confidence 0.68 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
These data indicate that Zic2 expression in the developing neural retina is necessary for the expression of Sert in iRGCs.
Positive_regulation (necessary) of Gene_expression (expression) of Sert in neural retina
2) Confidence 0.59 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Positive_regulation (causes) of Gene_expression (expression) of SERT in neurons
3) Confidence 0.57 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.75
We found increased expression of 5-HTT in RANKL-induced osteoclast-like cells.
Positive_regulation (increased) of Gene_expression (expression) of 5-HTT in osteoclast associated with fluoxetine
4) Confidence 0.45 Published 2004 Journal J. Bone Miner. Res. Section Abstract Doc Link 15312242 Disease Relevance 0 Pain Relevance 0.18
To further test whether Zic2 is required for Sert expression in the VT region of the retina, we examined Sert mRNA levels in Zic2 hypomorphic mutant mice (Zic2kd/kd).
Positive_regulation (required) of Gene_expression (expression) of Sert in retina
5) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
We also found that Sert expression is independent of EphB1.
Positive_regulation (independent) of Gene_expression (expression) of Sert
6) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.21 Pain Relevance 0
The transcription factor Pet1 is expressed in serotonergic neurons and directly activates the transcription of genes that are involved in the synthesis (Tph and Aadc) and uptake (Sert) of serotonin.
Positive_regulation (activates) of Gene_expression (synthesis) of Sert in serotonergic neurons associated with serotonin
7) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.58
Taking advantage of our previous observation that ectopic expression of Zic2 in the central retina induces the expression of Sert (Figure 3B), we took a gain-of-function approach instead.
Positive_regulation (induces) of Gene_expression (expression) of Sert in retina
8) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.05 Pain Relevance 0.03
Zic2 controls the transient expression of Sert during development
Positive_regulation (transient) of Gene_expression (expression) of Sert
9) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.08 Pain Relevance 0.29
Together, these results indicate that, in vivo, Zic2 is necessary and sufficient to induce Sert expression in the mouse retina.


Positive_regulation (sufficient) of Gene_expression (expression) of Sert in retina
10) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Zic2 is necessary and sufficient to induce the expression of Sert
Positive_regulation (sufficient) of Gene_expression (expression) of Sert
11) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Together, these results indicate that, in vivo, Zic2 is necessary and sufficient to induce Sert expression in the mouse retina.


Positive_regulation (necessary) of Gene_expression (expression) of Sert in retina
12) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Next, we assessed whether Zic2 is sufficient to induce Sert expression in vivo.
Positive_regulation (sufficient) of Gene_expression (expression) of Sert
13) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Zic2 is necessary and sufficient to induce the expression of Sert
Positive_regulation (necessary) of Gene_expression (expression) of Sert
14) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Spec (investigated) Positive_regulation (enzyme) of in embryos Gene_expression (production) of SLC6A4 in oocytes
15) Confidence 0.23 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Spec (investigated) Positive_regulation (enzyme) of in cumulus cells Gene_expression (production) of SLC6A4 in oocytes
16) Confidence 0.23 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
The short allele reduces transcriptional activity of the gene and results in decreased expression of the serotonin transporter.
Positive_regulation (results) of Gene_expression (expression) of serotonin transporter associated with serotonin
17) Confidence 0.22 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.17 Pain Relevance 0.09

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