INT120742

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.76
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
brain 4
neuronal 2
synaptic cleft 2
neurons 2
brainstem 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 11 99.46 Very High Very High Very High
Morphine 19 99.00 Very High Very High Very High
Antinociceptive 5 98.62 Very High Very High Very High
Endep 7 97.68 Very High Very High Very High
medulla 2 97.16 Very High Very High Very High
Locus ceruleus 6 96.20 Very High Very High Very High
opiate 8 93.32 High High
Electroencephalography 39 93.28 High High
Inflammatory response 1 92.20 High High
adenocard 18 89.48 High High
Disease Link Frequency Relevance Heat
Convulsion 189 98.54 Very High Very High Very High
INFLAMMATION 27 91.84 High High
Cancer 10 89.60 High High
Death 36 87.96 High High
Apoptosis 86 87.36 High High
Targeted Disruption 1 86.36 High High
Epilepsy 57 84.80 Quite High
Skin Cancer 2 84.16 Quite High
Prostate Cancer 2 83.36 Quite High
Arthritis 27 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABAB1R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group.
Negative_regulation (decreased) of Gene_expression (expression) of PKA in neuronal associated with convulsion
1) Confidence 0.24 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.19 Pain Relevance 0.29
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Negative_regulation (decrease) of Gene_expression (expression) of PKA in brain associated with convulsion
2) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.71 Pain Relevance 0.03
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Negative_regulation (decrease) of Gene_expression (expression) of PKA in brain associated with convulsion
3) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.71 Pain Relevance 0.03
In conclusion, our previously reported decreases in c-Fos and PKA expression in the NTS following pretreatment with low doses of naltrexone may be partially explained by a greater inhibition of NTS neurons resulting from increased muOR expression in this region.
Negative_regulation (decreases) of Gene_expression (expression) of PKA in neurons
4) Confidence 0.22 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.07 Pain Relevance 0.61
RESULTS: Withdrawal was attenuated and c-Fos, PKA, and pCREB expression was decreased in the NTS and LC of rats receiving chronic very low doses of naltrexone.
Negative_regulation (decreased) of Gene_expression (expression) of PKA
5) Confidence 0.22 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15312814 Disease Relevance 0 Pain Relevance 0
Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expression and intracellular signal transduction elements [protein kinase A regulatory subunit II (PKA) and phosphorylated cAMP response element binding protein (pCREB)] in brainstem noradrenergic nuclei.
Negative_regulation (decreased) of Gene_expression (expression) of PKA in brainstem associated with medulla and withdrawal
6) Confidence 0.16 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.56
These results show that acute amitriptyline treatment preserved morphine's antinociceptive effect in morphine-tolerant rats; the mechanisms may be involved in inhibition of phospho-PKA and PKC expression, and thus inducing the GLAST and GLT-1 trafficking onto glial cell surface which enhances the EAA uptake from the synaptic cleft and reduces EAA concentration in the spinal CSF.
Negative_regulation (inhibition) of Gene_expression (expression) of phospho-PKA in synaptic cleft associated with antinociceptive, endep and morphine
7) Confidence 0.15 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.65
Receptor activation leads to inhibition of adenylyl cyclase activity, inhibition of cAMP formation and inhibition of PKA expression, resulting in the initiation of various signaling pathways [14].
Negative_regulation (inhibition) of Gene_expression (expression) of PKA
8) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.01 Pain Relevance 0.68

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