INT120752

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 16.40
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
heart 8
coronary artery 4
myocardium 4
plasma 2
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 158 100.00 Very High Very High Very High
ischemia 149 99.96 Very High Very High Very High
imagery 5 99.36 Very High Very High Very High
Enkephalin 4 98.82 Very High Very High Very High
Angina 230 97.68 Very High Very High Very High
cva 6 97.04 Very High Very High Very High
cytokine 36 92.76 High High
Inflammatory response 21 54.56 Quite High
Catecholamine 8 38.80 Quite Low
metalloproteinase 55 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 185 100.00 Very High Very High Very High
Necrosis 142 100.00 Very High Very High Very High
Natriuresis 97 100.00 Very High Very High Very High
Coronary Heart Disease 69 100.00 Very High Very High Very High
Thrombosis 35 100.00 Very High Very High Very High
Cv Unclassified Under Development 100 99.96 Very High Very High Very High
Coronary Artery Disease 171 99.92 Very High Very High Very High
Stress 53 99.64 Very High Very High Very High
Death 132 99.52 Very High Very High Very High
Pressure And Volume Under Development 4 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ANP and BNP but not vascular endothelial growth factor (VEGF) and VEGF-receptor 1 and 2 were overexpressed in ischemic regions compared to non-ischemic regions as measured by real-time PCR.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of BNP
1) Confidence 0.67 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.63 Pain Relevance 0.22
ANP and BNP but not VEGF are regionally overexpressed in ischemic human myocardium.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of BNP in myocardium
2) Confidence 0.67 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15313204 Disease Relevance 0.59 Pain Relevance 0.22
The overexpression of ANP and BNP suggests an anti-angiogenic effect in ischemic heart disease.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BNP in heart associated with coronary artery disease
3) Confidence 0.67 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.57 Pain Relevance 0.19
The expression of B-type natriuretic peptide (BNP) was increased in hypocontractile relative to normally-contracting myocardium.
Positive_regulation (increased) of Gene_expression (expression) of B-type natriuretic peptide in myocardium associated with natriuresis
4) Confidence 0.59 Published 2008 Journal Eur. J. Heart Fail. Section Abstract Doc Link 18974021 Disease Relevance 0.34 Pain Relevance 0.08
Gene expression profiling of human hibernating myocardium: increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart.
Positive_regulation (increased) of Gene_expression (expression) of B-type natriuretic peptide in heart associated with natriuresis and enkephalin
5) Confidence 0.59 Published 2008 Journal Eur. J. Heart Fail. Section Title Doc Link 18974021 Disease Relevance 0.31 Pain Relevance 0.28
Post-traumatic alterations of NT-proBNP
Positive_regulation (alterations) of Gene_expression (alterations) of NT-proBNP
6) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.71 Pain Relevance 0.05
Measurement of plasma NT-proBNP levels
Positive_regulation (Measurement) of Gene_expression (levels) of NT-proBNP in plasma
7) Confidence 0.43 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 0.15 Pain Relevance 0
Serum NT-proBNP levels were elevated in all 26 patients.
Positive_regulation (elevated) of Gene_expression (levels) of NT-proBNP
8) Confidence 0.40 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2592747 Disease Relevance 1.19 Pain Relevance 0
Specifically, in human models of ischemia, BNP levels have been shown to increase transiently both after exercise in patients with stable coronary disease and after uncomplicated coronary angioplasty, despite stable intracardiac filling pressures.22,23 Others have shown the rise in the level of BNP is correlated with the size of an ischemic territory during nuclear stress imaging.24
Positive_regulation (after) of Gene_expression (levels) of BNP associated with stress, ischemia, coronary heart disease and imagery
9) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.21 Pain Relevance 0.12
Specifically, in human models of ischemia, BNP levels have been shown to increase transiently both after exercise in patients with stable coronary disease and after uncomplicated coronary angioplasty, despite stable intracardiac filling pressures.22,23 Others have shown the rise in the level of BNP is correlated with the size of an ischemic territory during nuclear stress imaging.24
Positive_regulation (increase) of Gene_expression (levels) of BNP associated with stress, ischemia, coronary heart disease and imagery
10) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.20 Pain Relevance 0.12
Specifically, in human models of ischemia, BNP levels have been shown to increase transiently both after exercise in patients with stable coronary disease and after uncomplicated coronary angioplasty, despite stable intracardiac filling pressures.22,23 Others have shown the rise in the level of BNP is correlated with the size of an ischemic territory during nuclear stress imaging.24
Positive_regulation (after) of Gene_expression (levels) of BNP associated with stress, ischemia, coronary heart disease and imagery
11) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.22 Pain Relevance 0.13
Specifically, in human models of ischemia, BNP levels have been shown to increase transiently both after exercise in patients with stable coronary disease and after uncomplicated coronary angioplasty, despite stable intracardiac filling pressures.22,23 Others have shown the rise in the level of BNP is correlated with the size of an ischemic territory during nuclear stress imaging.24
Positive_regulation (during) of Gene_expression (levels) of BNP associated with stress, ischemia, coronary heart disease and imagery
12) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.44 Pain Relevance 0.16
Many studies have been shown that elevation of BNP as well as NT-proBNP levels obtained after the acute phase (median, 40 to 72 hours after symptoms onset) in patients with a broad range of ACS independently predicts mortality.17–19 However, in most of the reports, authors do not distinguish subjects with low ejection fraction and LV enlargement; in all studies, BNP levels appear related to increase of heart failure, predicting of cardiac remodeling and pump dysfunction.
Spec (appear) Positive_regulation (appear) of Gene_expression (levels) of BNP in heart associated with acute coronary syndrome and myocardial infarction
13) Confidence 0.31 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.10 Pain Relevance 0.18
Although patients with the worse prognosis (with a relative risk of death to 30 days between 6.0 and 13.0) were those with combined increase of levels of cTnI (marker of thrombosis and myocardial necrosis), of CRP (expression of inflammatory status) and of BNP (marker of myocardial dysfunction).
Positive_regulation (increase) of Gene_expression (expression) of BNP associated with necrosis, inflammation, coronary heart disease, thrombosis and death
14) Confidence 0.22 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.05 Pain Relevance 0.10
BNP expression and release from cardiomyocites can also be stimulated by a variety of endocrine, paracrine and autocrine factors that are activated in heart failure, including norepinephrine, angiotensin II, ET-1, glucocorticoids and proinflammatory cytokines.
Positive_regulation (stimulated) of Gene_expression (expression) of BNP in heart associated with myocardial infarction and cytokine
15) Confidence 0.18 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.09 Pain Relevance 0.05
In this study MPO, sCD40L and MMP-9 levels were not independently associated with death, whereas patients with increased levels of PIGF, NT-proBNP, CRP, cTnI or decreased eGFR had higher mortality rate than patients with normal value of these biomarkers.
Positive_regulation (increased) of Gene_expression (levels) of NT-proBNP associated with urological neuroanatomy and death
16) Confidence 0.18 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.17 Pain Relevance 0
Elevated BNP and NT-pro-BNP levels have been observed in patients with stable coronary artery disease (CAD), in patients with UA (Kikuta K et al. 1996) and during and after Percutaneous coronary intervention (PCI) (Tateishi et al. 2000).
Positive_regulation (Elevated) of Gene_expression (levels) of NT-pro-BNP in coronary artery associated with angina and coronary artery disease
17) Confidence 0.16 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.22 Pain Relevance 0.15
Elevated BNP and NT-pro-BNP levels have been observed in patients with stable coronary artery disease (CAD), in patients with UA (Kikuta K et al. 1996) and during and after Percutaneous coronary intervention (PCI) (Tateishi et al. 2000).
Positive_regulation (Elevated) of Gene_expression (levels) of BNP in coronary artery associated with angina and coronary artery disease
18) Confidence 0.16 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.22 Pain Relevance 0.15

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