INT120761

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.40
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTP1) small molecule metabolic process (GSTP1) plasma membrane (GSTP1)
nucleus (GSTP1) intracellular (GSTP1) protein complex (GSTP1)
Anatomy Link Frequency
blood 1
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 1 82.48 Quite High
Inflammation 34 76.56 Quite High
tolerance 1 71.12 Quite High
alcohol 5 31.56 Quite Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
dorsal root ganglion 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 59 98.84 Very High Very High Very High
Necrosis 2 98.66 Very High Very High Very High
Cancer 74 98.48 Very High Very High Very High
Leukemia 5 97.08 Very High Very High Very High
Dysesthesia 13 96.64 Very High Very High Very High
Endometrial Cancer 67 96.14 Very High Very High Very High
Tinnitus 12 90.56 High High
Obesity 8 88.24 High High
Hearing Impairment 15 82.64 Quite High
INFLAMMATION 43 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
level and blood WBC count were evaluated after stratification according to the GSTM1 or GSTP1 gene polymorphism to estimate whether the GSTM1 and GSTP1 gene polymorphisms modify the relation between smoking and serum TNF-?
Spec (whether) Positive_regulation (polymorphisms) of GSTP1 in blood associated with nicotine addiction
1) Confidence 0.50 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.94 Pain Relevance 0.07
In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.
Positive_regulation (induced) of GSTP1-1 associated with leukemia, necrosis and cancer
2) Confidence 0.49 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.38 Pain Relevance 0.08
In our TCSs however, the cisplatin-dose is of overriding importance causing GSTP1-GG to disclose its protective potential.
Positive_regulation (causing) of GSTP1
3) Confidence 0.44 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.82 Pain Relevance 0.04
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Positive_regulation (enzyme) of GSTP1 associated with endometrial cancer
4) Confidence 0.17 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.27 Pain Relevance 0

General Comments

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