INT120762

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.66
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTP1) small molecule metabolic process (GSTP1) plasma membrane (GSTP1)
nucleus (GSTP1) intracellular (GSTP1) protein complex (GSTP1)
Anatomy Link Frequency
lung 1
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 68 97.56 Very High Very High Very High
Inflammatory marker 6 89.84 High High
qutenza 1 82.48 Quite High
Inflammatory response 10 72.32 Quite High
cytokine 4 58.40 Quite High
cINOD 2 45.92 Quite Low
peripheral neuropathy 6 39.60 Quite Low
alcohol 10 37.04 Quite Low
Paresthesia 9 5.00 Very Low Very Low Very Low
dysesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 61 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Stomach Cancer 72 98.90 Very High Very High Very High
Disease 66 98.24 Very High Very High Very High
Lung Cancer 5 98.00 Very High Very High Very High
INFLAMMATION 86 97.56 Very High Very High Very High
Leukemia 2 97.08 Very High Very High Very High
Nicotine Addiction 118 91.40 High High
Toxicity 33 66.32 Quite High
Stress 6 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results also suggest that GSTM1 and GSTP1 gene polymorphisms may be involved in the detoxification of toxic substances in cigarette smoke to change the levels of TNF-?
Regulation (polymorphisms) of GSTP1
1) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.04 Pain Relevance 0.23
In their study, when the effects of combined GSTM1 and GSTP1 genotypes on DNA adduct formation were examined, lung cancer patients with GSTM1 null and GSTP1 AG or GG genotype combinations had significantly higher carcinogen-derived DNA adduct level in lung tissue than those with the other genotype combinations.
Spec (examined) Regulation (effects) of GSTP1 in lung associated with lung cancer
2) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.86 Pain Relevance 0.23
In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.
Spec (examined) Regulation (effect) of GSTP1-1 associated with leukemia, necrosis and cancer
3) Confidence 0.32 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.39 Pain Relevance 0.08
Genetic Polymorphism of GSTP1: Prediction of Clinical Outcome to Oxaliplatin/5-FU-based Chemotherapy in Advanced Gastric Cancer

The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile105Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.

Regulation (value) of GSTP1 associated with stomach cancer
4) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2877230 Disease Relevance 0.52 Pain Relevance 0
Previous studies revealed that substitution of isoleucine with valine at codon 105 alters the function of the GSTP1 protein (20).
Regulation (alters) of GSTP1 protein
5) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877230 Disease Relevance 0.33 Pain Relevance 0
Genetic Polymorphism of GSTP1: Prediction of Clinical Outcome to Oxaliplatin/5-FU-based Chemotherapy in Advanced Gastric Cancer

The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile105Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.

Regulation (value) of S-transferase P1 associated with stomach cancer
6) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2877230 Disease Relevance 0.52 Pain Relevance 0

General Comments

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