INT120764

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.65
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 99.98 Very High Very High Very High
qutenza 1 99.56 Very High Very High Very High
Inflammation 46 97.48 Very High Very High Very High
cytokine 37 96.96 Very High Very High Very High
lidocaine 1 92.48 High High
Osteoarthritis 30 86.72 High High
Arthritis 9 77.24 Quite High
metalloproteinase 42 50.00 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 47 97.48 Very High Very High Very High
Leukemia 5 93.24 High High
Hypersensitivity 28 93.04 High High
Apoptosis 1 89.20 High High
Osteoarthritis 30 86.72 High High
Necrosis 5 85.88 High High
Cancer 9 85.52 High High
Arthritis 15 77.24 Quite High
Arthropathy 7 76.04 Quite High
Rhinitis 9 71.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interference of PPARalpha/retinoid X receptor alpha with the AP-1 transcription factor elements c-Jun/c-Fos resulted in the inhibition of AP-1 binding and down-regulation of the VDUP-1 gene expression.
Negative_regulation (inhibition) of AP-1 Binding (binding) of
1) Confidence 0.25 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18848838 Disease Relevance 0.20 Pain Relevance 0.16
Two hours of pretreatment with 2.5 and 10 mmol/l glucosamine significantly reduced c-jun DNA binding activity (P < 0.03; Figure 7), whereas junD binding activity was reduced to a lower degree (data not shown).


Negative_regulation (reduced) of c-jun Binding (activity) of
2) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.24 Pain Relevance 0.08
Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.
Negative_regulation (inhibit) of AP-1 Binding (binding) of associated with qutenza
3) Confidence 0.18 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.34 Pain Relevance 0.10
This approach has been shown to be effective in murine models.8 PPAR-gamma agonists inhibit gene expression by binding to AP1 and other coactivators inhibiting the production of important inflammatory cytokines.
Negative_regulation (inhibit) of AP1 Binding (binding) of associated with inflammation, agonist and cytokine
4) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.84 Pain Relevance 0.44
heterodimer to the DR-1 element precludes binding of AP-1 proteins to its site and thereby antagonizes the expression of MMP-1.
Negative_regulation (antagonizes) of AP-1 Binding (heterodimer) of
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.35 Pain Relevance 0.15
heterodimer to the DR-1 element precludes binding of AP-1 proteins to its site and thereby antagonizes the expression of MMP-1.
Negative_regulation (precludes) of AP-1 Binding (binding) of
6) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.15
heterodimer to the DR-1 element precludes binding of AP-1 proteins to its site and thereby antagonizes the expression of MMP-1.
Negative_regulation (precludes) of AP-1 Binding (heterodimer) of
7) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox