INT120807

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.62
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NOL3) intracellular (NOL3) cytoplasm (NOL3)
cytosol (NOL3) RNA binding (NOL3) nucleolus (NOL3)
Anatomy Link Frequency
neocortex 1
molar 1
temporal lobe 1
NOL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 43 100.00 Very High Very High Very High
Opioid 8 99.90 Very High Very High Very High
opioid receptor 10 99.56 Very High Very High Very High
Kinase C 3 99.00 Very High Very High Very High
narcan 1 98.74 Very High Very High Very High
Buprenorphine 1 98.48 Very High Very High Very High
agonist 9 98.00 Very High Very High Very High
antagonist 9 95.88 Very High Very High Very High
qutenza 3 94.40 High High
Pain 3 94.08 High High
Disease Link Frequency Relevance Heat
Epilepsy 15 99.02 Very High Very High Very High
Cough 10 99.00 Very High Very High Very High
Pain 3 94.08 High High
Anxiety Disorder 1 93.60 High High
Stress 1 92.88 High High
Appetite Loss 1 91.68 High High
Urinary Dysfunction 1 90.32 High High
Pressure And Volume Under Development 1 88.72 High High
Drug Dependence 1 88.16 High High
Sclerosis 6 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCH 486757 selectively binds human NOP receptor (K(i)=4.6+/-0.61nM) over classical opioid receptors.
NOP receptor Binding (binds) of associated with opioid receptor
1) Confidence 0.45 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20006596 Disease Relevance 0.36 Pain Relevance 0.56
In conclusion, our present data obtained from neocortex of epileptic patients provide strong evidence that a) temporal lobe epilepsy is associated with alterations in mu opioid and NOP receptor binding and signal transduction mechanisms downstream of these receptors, and b) clinical aspects may play an important role on these receptor changes.
NOP receptor Binding (binding) of in temporal lobe associated with epilepsy, orphanin and opioid
2) Confidence 0.38 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 0.94 Pain Relevance 0.57
Nociceptin/orphanin FQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the G-protein coupled receptor ORL1 (NOP), a member of the opioid receptor family.
NOP Binding (ligand) of associated with orphanin and opioid receptor
3) Confidence 0.37 Published 2004 Journal J. Pept. Res. Section Abstract Doc Link 15317498 Disease Relevance 0 Pain Relevance 0.27
Buprenorphine and naloxone benzoylhydrazone are two opioid receptor ligands showing high affinity for NOP receptors.
NOP Binding (affinity) of associated with narcan, opioid receptor and buprenorphine
4) Confidence 0.36 Published 2007 Journal Curr Drug Targets Section Abstract Doc Link 17266536 Disease Relevance 1.39 Pain Relevance 1.03
The aim of this work was to evaluate the level of G-proteins activation mediated by DAMGO (a mu receptor selective peptide) and nociceptin, and the binding to mu and nociceptin (NOP) receptors and adenylyl cyclase (AC) in neocortex of patients with pharmacoresistant temporal lobe epilepsy.
NOP Binding (binding) of in neocortex associated with epilepsy and orphanin
5) Confidence 0.29 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 0.79 Pain Relevance 0.47
Herein, we describe the pharmacologic activity of a series of modified amino acid containing modifications of the hexapeptide Ac-RYYRWR-NH2, with high affinity for NOP.
NOP Binding (affinity) of
6) Confidence 0.24 Published 2004 Journal J. Pept. Res. Section Abstract Doc Link 15317498 Disease Relevance 0 Pain Relevance 0.25
These compounds were tested for binding affinity using [3H]N/OFQ binding to human NOP in CHO cells, and functional activity by measuring stimulation of [35S]GTPgammaS-binding in CHO cell membranes.
NOP Binding (binding) of
7) Confidence 0.24 Published 2004 Journal J. Pept. Res. Section Abstract Doc Link 15317498 Disease Relevance 0 Pain Relevance 0.24
These data suggest that OFQ/N binds to NOP receptors and activates protein kinase C, which then increases the ability of GRK2 to phosphorylate the agonist-occupied mu receptor, heterologously regulating homologous mu receptor desensitization.
NOP Binding (binds) of associated with kinase c and agonist
8) Confidence 0.23 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.06 Pain Relevance 0.41
Taken together, the high molar activity, improved chemical and biological stability and the capability of the selective and high affinity labeling make this novel radioprobe available for further exploring the biochemical pharmacology and receptor-ligand interaction of the NOP receptor.
NOP receptor Binding (interaction) of in molar
9) Confidence 0.05 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19414055 Disease Relevance 0 Pain Relevance 0.16
RESULTS: SCH 225288 selectively binds human NOP receptor (K(i) = 0.38 +/- 0.02 nmol/l) over classical opioid receptors (COR).
NOP receptor Binding (binds) of
10) Confidence 0.02 Published 2009 Journal Pharmacology Section Body Doc Link 19696521 Disease Relevance 0.08 Pain Relevance 0

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