INT12081

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 64
Total Number 67
Disease Relevance 35.40
Pain Relevance 17.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
fibroblast 4
PBMC 4
platelet 2
AEC2 2
dentin 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 425 100.00 Very High Very High Very High
fibrosis 117 100.00 Very High Very High Very High
Morphine 54 99.84 Very High Very High Very High
Osteoarthritis 151 99.68 Very High Very High Very High
addiction 7 99.68 Very High Very High Very High
Peripheral nervous system 9 99.64 Very High Very High Very High
Inflammation 630 99.44 Very High Very High Very High
Neuropeptide 6 99.42 Very High Very High Very High
Somatostatin 4 99.40 Very High Very High Very High
narcan 7 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 505 100.00 Very High Very High Very High
Fibrosis 163 100.00 Very High Very High Very High
Syndrome 77 100.00 Very High Very High Very High
Necrosis 51 100.00 Very High Very High Very High
Camurati-engelmann Disease 3 100.00 Very High Very High Very High
Hypercalcemia 71 99.98 Very High Very High Very High
Primary Sclerosing Cholangitis 330 99.88 Very High Very High Very High
Osteoarthritis 154 99.68 Very High Very High Very High
Infection 113 99.66 Very High Very High Very High
Osteoporosis 127 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis.
Localization (Localization) of transforming growth factor beta 1 associated with chronic pancreatitis
1) Confidence 0.81 Published 1995 Journal Gastroenterology Section Title Doc Link 7768393 Disease Relevance 0.29 Pain Relevance 0.28
The amplifying effect of morphine on the release of TGF-beta was mediated through a naloxone-sensitive mechanism.
Localization (release) of TGF-beta associated with narcan and morphine
2) Confidence 0.77 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.15 Pain Relevance 0.82
Upon stimulation with lipopolysaccharide and phytohemagglutinin, PBMC released more (P less than .01) TGF-beta, IL-6 and TNF-alpha than unstimulated PBMC.
Localization (released) of TGF-beta in PBMC
3) Confidence 0.77 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.18 Pain Relevance 0.77
Morphine (1 pM and 10 nM) alone did not significantly modulate the release of TGF-beta, IL-6 or TNF-alpha.
Localization (release) of TGF-beta associated with morphine
4) Confidence 0.77 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.19 Pain Relevance 0.69
Exposure of PBMC to morphine (1 pM) for 24 hr substantially amplified (P less than .05) the release of TGF-beta in the following 24 hr incubation period.
Localization (release) of TGF-beta in PBMC associated with morphine
5) Confidence 0.77 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.17 Pain Relevance 0.80
Given the fact that TGF-beta has a potent immunosuppressive effect, morphine-potentiated release of TGF-beta from PBMC may be involved in the immunomodulatory activity ascribed to morphine.
Localization (release) of TGF-beta in PBMC associated with morphine
6) Confidence 0.77 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.14 Pain Relevance 0.80
The potential use of TGF-?
Localization (use) of TGF
7) Confidence 0.72 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 1.10 Pain Relevance 0.44
During pulp injury, it has been hypothesized that transforming growth factor-beta1 (TGF-beta1) is released from dentin into pulp tissue and promotes pulp tissue healing.
Localization (released) of transforming growth factor-beta1 in dentin associated with injury
8) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.35
During pulp injury, it has been hypothesized that transforming growth factor-beta1 (TGF-beta1) is released from dentin into pulp tissue and promotes pulp tissue healing.
Localization (released) of TGF-beta1 in dentin associated with injury
9) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.35
We analyzed apoptosis (TUNEL: DNA fragmentation); cell proliferation (immunohistochemistry (IHC) for Ki67); c-myc, bax and TGF-beta1 mRNA abundance (RT-PCR) and TGF-beta1 protein (IHC) in endometrial explants.


Localization (abundance) of TGF-beta1 protein associated with apoptosis
10) Confidence 0.66 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1262771 Disease Relevance 0.92 Pain Relevance 0.26
We analyzed apoptosis (TUNEL: DNA fragmentation); cell proliferation (immunohistochemistry (IHC) for Ki67); c-myc, bax and TGF-beta1 mRNA abundance (RT-PCR) and TGF-beta1 protein (IHC) in endometrial explants.


Localization (abundance) of TGF-beta1 associated with apoptosis
11) Confidence 0.66 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1262771 Disease Relevance 0.92 Pain Relevance 0.25
Each rabbit received the indicated dose of TGF-?
Localization (dose) of TGF
12) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.21 Pain Relevance 0.10
In addition, only the highest dose of Ad.TGF-?
Localization (dose) of TGF
13) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.31 Pain Relevance 0.12
The joints of naïve rabbits receiving the highest dose of Ad.TGF-?
Localization (dose) of TGF in joints
14) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.58 Pain Relevance 0.24
Transforming growth factor beta (TGFbeta), which is abundant in bone matrix and is released as a consequence of osteoclastic bone resorption, may promote breast carcinoma osteolysis by stimulating PTHrP production by tumor cells.
Localization (released) of TGFbeta associated with cancer, breast cancer, osteolysis, hypercalcemia and osteoporosis
15) Confidence 0.63 Published 2000 Journal Cancer Section Abstract Doc Link 10898330 Disease Relevance 1.28 Pain Relevance 0.09
g/L, This range is very important in the future therapeutic applications of the TGF-?
Localization (applications) of TGF
16) Confidence 0.62 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.25 Pain Relevance 0
In addition, the dose-dependent effect of TGF-?
Localization (effect) of TGF
17) Confidence 0.62 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.25 Pain Relevance 0
Role of TGF-?
Localization (Role) of TGF
18) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.39 Pain Relevance 0.53
Nevertheless, in cultured VSMC the importance of TGF-?
Localization (importance) of TGF
19) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.49 Pain Relevance 0.56
Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures.
Localization (release) of transforming growth factor-beta in mononuclear cell associated with morphine
20) Confidence 0.59 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1625199 Disease Relevance 0.17 Pain Relevance 0.68

General Comments

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