INT120810

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 3.55
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spine 2
synapses 2
Shank 1
tail 1
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 396 100.00 Very High Very High Very High
Glutamate receptor 168 100.00 Very High Very High Very High
depression 128 97.12 Very High Very High Very High
sodium channel 1 94.16 High High
Peripheral nervous system 1 92.88 High High
Hippocampus 147 90.96 High High
long-term potentiation 300 90.00 High High
Pain 27 88.56 High High
Pyramidal cell 93 86.88 High High
Dynorphin 8 86.12 High High
Disease Link Frequency Relevance Heat
Disease 168 99.28 Very High Very High Very High
Anxiety Disorder 305 98.16 Very High Very High Very High
Depression 128 97.12 Very High Very High Very High
Targeted Disruption 173 96.72 Very High Very High Very High
Schizophrenia 157 86.36 High High
Generalized Anxiety Disorder 2 81.20 Quite High
Congenital Anomalies 57 80.60 Quite High
Adhesions 30 76.64 Quite High
Shock 36 64.16 Quite High
Manic Depressive Disorder 15 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As PSD-95/Dlg4 was the bait for the biochemical isolation of the complexes, we examined the distribution of its primary interactors (proteins that directly bind PSD-95) and secondary interactors (proteins that do not bind PSD-95 directly, but bind one of its primary interactors) (Figure 5A).
PSD-95 Neg (not) Binding (bind) of
1) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.07
PSD-95 binds NMDA-Rs [29,30] and also interacts with AMPA-Rs via TARPs [31,32].
PSD-95 Binding (binds) of
2) Confidence 0.41 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.08 Pain Relevance 0
We first intercrossed PSD-95TAP heterozygous mice (PSD-95TAP/+) and found no distortion of transmission frequency in the offspring of PSD-95TAP/+ intercrosses (data not shown).
PSD-95TAP Binding (intercrossed) of
3) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0
Although PSD-95 is a known direct binding partner of NMDA receptors, there is conflicting data about physical interactions between PSD-95 and AMPA receptor subunits.
PSD-95 Binding (interactions) of associated with nmda receptor
4) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0.08
Although PSD-95 is a known direct binding partner of NMDA receptors, there is conflicting data about physical interactions between PSD-95 and AMPA receptor subunits.
PSD-95 Binding (binding) of associated with nmda receptor
5) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0.09
Although PSD-95 is a known direct binding partner of NMDA receptors, there is conflicting data about physical interactions between PSD-95 and AMPA receptor subunits.
PSD-95 Binding (binding) of associated with nmda receptor
6) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0.09
Interactions between PSD-95 molecules in the PSD are also likely required to maintain stable PSD-95 clusters [72].
PSD-95 Binding (Interactions) of
7) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
However, several prominent structural molecules that bind to PSD-95 directly or indirectly, including GKAP, Shank, and CaMKII, are developmentally regulated [75–78].
PSD-95 Binding (bind) of in Shank
8) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
However, this explanation is likely not sufficient because PSD-95 binding partners are also unstable [23,59], with half-lives at synapses on the order of minutes to hours [60,61].
PSD-95 Binding (binding) of in synapses
9) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
PSD size should also play a role, since the number of binding sites for PSD-95 in the PSD is likely proportional to PSD size, larger PSDs could capture more PSD-95.
PSD-95 Binding (binding) of
10) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
PSD-95 is an abundant multi-domain postsynaptic scaffolding protein that clusters glutamate receptors and organizes the associated signaling complexes.
PSD-95 Binding (organizes) of associated with glutamate receptor
11) Confidence 0.36 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.05
In the third stage, the complex was recovered from solution by Ni2+–NTA–agarose column that binds the HAT-tagged PSD-95.
PSD-95 Binding (binds) of
12) Confidence 0.35 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.06 Pain Relevance 0
As PSD-95/Dlg4 was the bait for the biochemical isolation of the complexes, we examined the distribution of its primary interactors (proteins that directly bind PSD-95) and secondary interactors (proteins that do not bind PSD-95 directly, but bind one of its primary interactors) (Figure 5A).
PSD-95 Spec (examined) Binding (bind) of
13) Confidence 0.35 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.07
The recovery of PSD-95 using a Ni2+–NTA–agarose column that binds the HAT-tagged PSD-95 was very efficient (>95%) (Figure 3C, lanes 2 and 3, TEV El, SN).
PSD-95 Binding (binds) of
14) Confidence 0.35 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0
Composition and organization of PSD-95 interaction networks
PSD-95 Binding (interaction) of
15) Confidence 0.32 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0
A total of 16 proteins were common to PSD-95 MCC and MASC MCC (P<10e?
PSD-95 MCC Binding (common) of
16) Confidence 0.32 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.19 Pain Relevance 0.05
Characterization of TAP-tagged PSD-95-associated complexes
TAP-tagged PSD-95 Binding (Characterization) of
17) Confidence 0.32 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0
It is likely that the underlying true decay is multi-exponential, reflecting heterogeneous interactions of PSD-95 with its binding partners.
PSD-95 Binding (interactions) of
18) Confidence 0.32 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Although the interactions of PSD-95 with its binding partners in the PSD set the magnitude of ?
PSD-95 Binding (interactions) of
19) Confidence 0.32 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
r (Figure 3), compartmentalization of PSD-95 by the spine can still influence the value of ?
PSD-95 Binding (compartmentalization) of in spine
20) Confidence 0.32 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0

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