INT120814

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.99
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
spinal cord 1
dorsal root ganglia 1
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.76 Very High Very High Very High
Pain 6 99.64 Very High Very High Very High
aPETx2 2 98.88 Very High Very High Very High
Lasting pain 4 98.44 Very High Very High Very High
sodium channel 3 97.70 Very High Very High Very High
Action potential 1 94.08 High High
antagonist 6 88.32 High High
nociceptor 2 84.92 Quite High
ASIC 32 82.24 Quite High
Peripheral nervous system 2 78.24 Quite High
Disease Link Frequency Relevance Heat
Pain 6 98.44 Very High Very High Very High
Acidosis 16 87.04 High High
Disease 10 75.20 Quite High
INFLAMMATION 2 74.56 Quite High
Death 16 47.52 Quite Low
Toxicity 12 9.96 Low Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Brain Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord.
Negative_regulation (co-precipitated) of ASIC3 in spinal cord associated with spinal cord
1) Confidence 0.28 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.37
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Negative_regulation (inhibitors) of ASIC3 associated with pain
2) Confidence 0.21 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19339181 Disease Relevance 0 Pain Relevance 0.19
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Negative_regulation (inhibitors) of ASIC3
3) Confidence 0.21 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19553111 Disease Relevance 0 Pain Relevance 0.09
A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.
Negative_regulation (inhibitors) of ASIC3 associated with lasting pain
4) Confidence 0.21 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19553111 Disease Relevance 0.10 Pain Relevance 0.10
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
Negative_regulation (inhibitors) of ASIC3 associated with lasting pain
5) Confidence 0.21 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19339181 Disease Relevance 0.10 Pain Relevance 0.10
While PSD-95 decreased surface ASIC3 and ASIC3-mediated currents, Lin-7b increased surface ASIC3 and ASIC3-mediated current.
Negative_regulation (surface) of ASIC3
6) Confidence 0.10 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
While PSD-95 decreased surface ASIC3 and ASIC3-mediated currents, Lin-7b increased surface ASIC3 and ASIC3-mediated current.
Negative_regulation (surface) of ASIC3-mediated
7) Confidence 0.10 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord.
Negative_regulation (co-precipitated) of ASIC3 in dorsal root ganglia associated with spinal cord
8) Confidence 0.09 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.37
The pH-induced relaxation of airway basal tone was inhibited by pretreatments with ASIC1a or ASIC3/ASIC2a inhibitors (0.5 mM ibuprofen, 0.1 mM gadolinium), nitric oxide synthase inhibitor (1 mM L-NAME), and guanylate cyclase inhibitor (1 microM ODQ).
Negative_regulation (inhibitor) of ASIC3
9) Confidence 0.07 Published 2007 Journal Life Sci. Section Abstract Doc Link 17869310 Disease Relevance 0.40 Pain Relevance 0.45
The pH-induced relaxation of airway basal tone was inhibited by pretreatments with ASIC1a or ASIC3/ASIC2a inhibitors (0.5 mM ibuprofen, 0.1 mM gadolinium), nitric oxide synthase inhibitor (1 mM L-NAME), and guanylate cyclase inhibitor (1 microM ODQ).
Negative_regulation (inhibitor) of ASIC3
10) Confidence 0.07 Published 2007 Journal Life Sci. Section Abstract Doc Link 17869310 Disease Relevance 0.40 Pain Relevance 0.36
Circular dichroism spectra of BcIII and BcIV show a high content of beta-strand secondary structure in both peptides, very similar to type 1 sodium channel toxins from various sea anemones, and to APETx1 and APETx2 from A. elegantissima, a HERG channel modulator and an ASIC3 inhibitor, respectively.
Negative_regulation (inhibitor) of ASIC3 associated with sodium channel and apetx2
11) Confidence 0.06 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17015047 Disease Relevance 0 Pain Relevance 0.27

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