INT120819

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC3, Lin7b) signal transduction (ASIC3) transport (ASIC3)
cytoplasm (ASIC3)
ASIC3 (Homo sapiens)
Lin7b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 2 95.44 Very High Very High Very High
Peripheral nervous system 2 94.16 High High
nociceptor 2 93.72 High High
Spinal cord 4 92.00 High High
Pain 2 90.64 High High
Mechanosensation 2 50.72 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that a PDZ-binding motif at the ASIC3 C terminus interacts with four different proteins that contain PDZ domains: PSD-95, Lin-7b, MAGI-1b, and PIST.
ASIC3 Binding (interacts) of Lin-7b
1) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.36
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.
acid-sensing ion channel-3 Binding (interact) of Lin-7b
2) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.37

General Comments

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