INT12082

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 365
Total Number 369
Disease Relevance 241.78
Pain Relevance 105.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
fibroblasts 14
macrophages 10
astrocytes 8
plasma 7
microglia 7
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4848 100.00 Very High Very High Very High
cytokine 4059 100.00 Very High Very High Very High
chemokine 449 100.00 Very High Very High Very High
Inflammatory mediators 265 100.00 Very High Very High Very High
fibrosis 205 100.00 Very High Very High Very High
Cholecystokinin 1 99.90 Very High Very High Very High
cINOD 309 99.88 Very High Very High Very High
Arthritis 774 99.84 Very High Very High Very High
agonist 498 99.82 Very High Very High Very High
rheumatoid arthritis 1061 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5938 100.00 Very High Very High Very High
Cancer 3342 100.00 Very High Very High Very High
Obesity 1057 100.00 Very High Very High Very High
Necrosis 366 100.00 Very High Very High Very High
Adhesions 341 100.00 Very High Very High Very High
Cardiovascular Disease 337 100.00 Very High Very High Very High
Hypoxia 136 100.00 Very High Very High Very High
Anaemia 93 100.00 Very High Very High Very High
Cystic Fibrosis 31 100.00 Very High Very High Very High
Myxoma 17 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 was spontaneously secreted from RA and OA synovial membranes.
Localization (secreted) of IL-6 associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.81 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.94 Pain Relevance 0.70
In patients with OA or RA, this electrically induced reduction of IL-6 secretion was not significantly changed by alpha- or beta-adrenergic antagonists.
Localization (secretion) of IL-6 associated with antagonist, rheumatoid arthritis and osteoarthritis
2) Confidence 0.81 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.90 Pain Relevance 0.70
Electrical field stimulation intensively reduced IL-6 secretion.
Localization (secretion) of IL-6
3) Confidence 0.81 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.93 Pain Relevance 0.70
Samples of tissues of normal pancreas (n=5) and CP (n=16), were verified histopathologically and then IL-6 was localized by immunohistochemical staining using the monoclonal antihuman IL-6 antibody and test LSAB2-HRP to visualize IL-6/Ab complexes.
Localization (localized) of IL-6 in pancreas associated with chronic pancreatitis
4) Confidence 0.81 Published 2008 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 18091322 Disease Relevance 0.58 Pain Relevance 0.50
IL-6 was localized in exocrine, islet cells and ducts cells of the pancreas.
Localization (localized) of IL-6 in ducts
5) Confidence 0.81 Published 2008 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 18091322 Disease Relevance 0.66 Pain Relevance 0.59
The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6.
Localization (release) of IL-6 in plasma associated with catecholamine
6) Confidence 0.80 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7611579 Disease Relevance 0.16 Pain Relevance 0.16
The SNP infusion exerted an important additional stimulus for IL-6 release after relatively mild surgical trauma in both groups.
Localization (release) of IL-6 associated with injury
7) Confidence 0.80 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7611579 Disease Relevance 0.17 Pain Relevance 0.16
The regulation of interleukin-6 secretion by prostanoids and members of the tumor necrosis factor superfamily in fresh villous fragments of term human placenta.
Localization (secretion) of interleukin-6 in placenta associated with necrosis and cancer
8) Confidence 0.80 Published 2004 Journal J. Soc. Gynecol. Investig. Section Title Doc Link 15051033 Disease Relevance 0.29 Pain Relevance 0.19
OBJECTIVE: To determine whether prostanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and members of the tumor necrosis factor superfamily can regulate placental secretion of interleukin-6 (IL-6) and whether labor influences any such effects.
Localization (secretion) of interleukin-6 associated with necrosis, inflammation, cancer and cinod
9) Confidence 0.80 Published 2004 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15051033 Disease Relevance 0.45 Pain Relevance 0.20
OBJECTIVE: To determine whether prostanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and members of the tumor necrosis factor superfamily can regulate placental secretion of interleukin-6 (IL-6) and whether labor influences any such effects.
Localization (secretion) of IL-6 associated with necrosis, inflammation, cancer and cinod
10) Confidence 0.80 Published 2004 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15051033 Disease Relevance 0.45 Pain Relevance 0.20
RESULTS: Wounded cells exposed to 5 J/cm(2) using 632.8 nm showed an increase in cell migration and haptotaxis, a stable increase in the release of interleukin-6 (IL-6), a decrease in caspase 3/7 activity, an increase in ATP viability and an increase in cell proliferation--1 h after the final exposure.
Localization (release) of IL-6
11) Confidence 0.80 Published 2008 Journal Photodermatol Photoimmunol Photomed Section Body Doc Link 18717961 Disease Relevance 0 Pain Relevance 0
Thus, pro-inflammatory cytokines such as TNFalpha, IL1 beta and IL6 are released into the bloodstream both from the liver and from distal sites during hepatic toxic injury.
Localization (released) of IL6 in liver associated with inflammation, injury and cytokine
12) Confidence 0.79 Published 2005 Journal Cancer biomarkers : section A of Disease markers Section Abstract Doc Link 17192030 Disease Relevance 1.15 Pain Relevance 0.42
Paracetamol (0.01-1000 microM), an unusual analgesic/antipyretic drug which acts preferentially by reducing prostaglandin production within the central nervous system, and indomethacin (0.001-10 microM) caused a clear dose-dependent reduction of prostaglandin E2 production by stimulated T98G cells whereas interleukin-6 release was not affected.
Localization (release) of interleukin-6 in central nervous system associated with paracetamol, analgesic and central nervous system
13) Confidence 0.79 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845273 Disease Relevance 0.64 Pain Relevance 0.56
Furthermore, prostaglandins can stimulate T98G to secrete interleukin-6, which in turn triggers the formation of additional prostaglandins.
Localization (secrete) of interleukin-6 in T98G
14) Confidence 0.79 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845273 Disease Relevance 0.76 Pain Relevance 0.39
The present study shows that beta-amyloid can stimulate human astrocytoma cells (T98G) to secrete the proinflammatory factors interleukin-6 and prostaglandins.
Localization (secrete) of interleukin-6 in T98G associated with anaplastic astrocytoma and alzheimer's dementia
15) Confidence 0.79 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845273 Disease Relevance 0.78 Pain Relevance 0.37
participates in the innate acute inflammatory response by inducing the secretion of chemokines, which stimulate a second wave of cytokines, including IL-6, IL-8 and C-reactive protein [14,15].
Localization (secretion) of IL-6 associated with chemokine, inflammatory response and cytokine
16) Confidence 0.79 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 1.03 Pain Relevance 0.37
Febbraio et al. (2002) suggested that the release of IL-6 could be stimulated by calcium (Ca2+) as a means of maintaining metabolism in homeostasis, specially in eccentric and concentric contraction [23].
Localization (release) of IL-6
17) Confidence 0.79 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.22 Pain Relevance 0.21
They inferred that IL-6 release probably occurred through a route independent of the release of TNF-?
Spec (probably) Localization (release) of IL-6
18) Confidence 0.79 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.33 Pain Relevance 0.17
Similarly, the literature provides evidence of IL-6 release after strenuous exercise in elderly persons and in youth.
Localization (release) of IL-6
19) Confidence 0.79 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.27 Pain Relevance 0.09
They inferred that IL-6 release probably occurred through a route independent of the release of TNF-?.
Spec (probably) Localization (release) of IL-6
20) Confidence 0.79 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.28 Pain Relevance 0.27

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