INT120820

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ASIC3, Dlg4) cytoplasm (ASIC3, Dlg4) signal transduction (ASIC3)
transport (ASIC3) structural molecule activity (Dlg4) protein complex assembly (Dlg4)
ASIC3 (Homo sapiens)
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 2 95.44 Very High Very High Very High
Peripheral nervous system 2 94.16 High High
nociceptor 2 93.72 High High
Spinal cord 4 91.36 High High
Pain 3 90.64 High High
ASIC 11 89.12 High High
Kinase C 1 68.96 Quite High
Mechanosensation 2 50.72 Quite High
Dopamine 2 24.96 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 54.40 Quite High
Acidosis 4 53.64 Quite High
Toxicity 6 16.84 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that a PDZ-binding motif at the ASIC3 C terminus interacts with four different proteins that contain PDZ domains: PSD-95, Lin-7b, MAGI-1b, and PIST.
ASIC3 Binding (interacts) of PSD-95
1) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.36
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.
acid-sensing ion channel-3 Binding (interact) of PSD-95
2) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.37
PSD-95 and several other PDZ domain-containing proteins including Lin-7b, MAGI-1b and PIST were also found to interact with ASIC2a and ASIC3 [6,39].
ASIC3 Binding (interact) of PSD-95
3) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.11 Pain Relevance 0.12

General Comments

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