INT12083

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Context Info
Confidence 0.53
First Reported 1991
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 15.40
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
basement membrane 2
chondrocytes 1
muscle 1
skeletal muscle cells 1
dermis 1
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 74 100.00 Very High Very High Very High
Morphine 8 99.08 Very High Very High Very High
metalloproteinase 25 98.62 Very High Very High Very High
Osteoarthritis 91 98.48 Very High Very High Very High
carpal tunnel syndrome 6 98.00 Very High Very High Very High
Inflammation 174 94.72 High High
Pain 54 92.96 High High
Chronic pancreatitis 70 92.72 High High
fibrosis 80 81.12 Quite High
opiate 1 80.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 100 100.00 Very High Very High Very High
Fibrosis 82 100.00 Very High Very High Very High
Hypercalcemia 16 100.00 Very High Very High Very High
Osteoporosis 9 100.00 Very High Very High Very High
Syndrome 95 99.98 Very High Very High Very High
Injury 74 99.98 Very High Very High Very High
Breast Cancer 62 99.44 Very High Very High Very High
Aging 26 99.44 Very High Very High Very High
Pancreatic Cancer 21 99.40 Very High Very High Very High
Camurati-engelmann Disease 8 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The growth regulatory properties of EGR1 have been found to involve coordinated regulation of TGF-?
Regulation (regulation) of TGF
1) Confidence 0.53 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.29 Pain Relevance 0
The immunohistochemical studies demonstrated increased deposition of TGF-beta, type VI collagen, and fibronectin epitopes in the extracellular matrix of the fascia in comparison to the adjacent dermis in the same specimens.
Regulation (epitopes) of TGF-beta in dermis
2) Confidence 0.44 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.75 Pain Relevance 0.03
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
Neg (neither) Regulation (altered) of TGFbeta associated with metalloproteinase and cytokine
3) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.43 Pain Relevance 0.24
To assess whether these effects were dependent on TGFbeta, its levels in cell culture supernatants were analyzed by ELISA.
Spec (whether) Regulation (dependent) of TGFbeta
4) Confidence 0.27 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.92 Pain Relevance 0.34
Morphine (1 pM and 10 nM) alone did not significantly modulate the release of TGF-beta, IL-6 or TNF-alpha.
Neg (not) Regulation (modulate) of TGF-beta associated with morphine
5) Confidence 0.26 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.19 Pain Relevance 0.69
Change in transforming growth factor beta signaling in ageing chondrocytes and osteoarthritis
Regulation (Change) of transforming growth factor beta in chondrocytes associated with aging and osteoarthritis
6) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.60 Pain Relevance 0.15
The genetic mutation underlying JPS involves the transforming growth factor-?
Regulation (involves) of transforming growth factor associated with syndrome
7) Confidence 0.25 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.77 Pain Relevance 0
Moreover, the effects of transforming growth factor beta 1(TGFbeta1) or platelet-derived growth factor stimulation and of cultivation on basement membrane components or N-acetylcysteine (NAC) treatment on gene and protein expression and proliferation were analyzed.
Spec (analyzed) Regulation (effects) of TGFbeta1 in basement membrane
8) Confidence 0.24 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.11 Pain Relevance 0.15
Moreover, the effects of transforming growth factor beta 1(TGFbeta1) or platelet-derived growth factor stimulation and of cultivation on basement membrane components or N-acetylcysteine (NAC) treatment on gene and protein expression and proliferation were analyzed.
Spec (analyzed) Regulation (effects) of transforming growth factor beta 1 in basement membrane
9) Confidence 0.24 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.10 Pain Relevance 0.15
The goal of the current study was to determine LO activity and the effects of TGF beta 1 on LO expression in the cells from patients with CTS.
Regulation (effects) of TGF beta 1 associated with carpal tunnel syndrome
10) Confidence 0.22 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10874650 Disease Relevance 0.53 Pain Relevance 0.53
We found that patient classification models built on the expression values of TGFB1 and PTEN could correctly classify 72% of these samples using a linear support vector machine classifier (SVM) and leave-one-out cross-validation (LOO).
Regulation (values) of TGFB1
11) Confidence 0.21 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.13 Pain Relevance 0
Further, recognizing the potential role for pulmonary remodeling involving collagen and elastin synthesis in emphysema (Vlahovic et al 1999), we sought to define the pattern of regulation of the pro-fibrotic cytokine, transforming growth factor beta (TGF-?)
Regulation (regulation) of transforming growth factor beta associated with fibrosis, emphysema and cytokine
12) Confidence 0.13 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706618 Disease Relevance 0.69 Pain Relevance 0.23
Thus, serine protease inhibitors act on hPFCs to diminish the effects of PDGF on proliferation and the effects of TGF-beta1 on collagen synthesis.
Regulation (effects) of TGF-beta1
13) Confidence 0.10 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.06 Pain Relevance 0.06
The effect of various cytokines and osteoinductive growth factors, such as BMP-2, BMP-7, or rhBMP-12, TGF-beta1, TGF-beta2, TGF-beta3, and fibroblast growth factor, have been tested for TBI healing enhancement.
Regulation (effect) of TGF-beta1 in fibroblast associated with cytokine
14) Confidence 0.07 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2931497 Disease Relevance 0.08 Pain Relevance 0.10
Immunoreactivities of iNOS and TGF-beta in the non-fluid resuscitated group were increased significantly, in comparison to the other groups, apart from the dextran-70 treated group.
Regulation (Immunoreactivities) of TGF-beta
15) Confidence 0.06 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.16 Pain Relevance 0.05
The soy isoflavones have additionally been proposed to regulate the proliferation of breast epithelia via an alternative mechanism involving the modulation of TGF-?
Regulation (modulation) of TGF
16) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.31 Pain Relevance 0
Halofuginone did not affect TGFbeta levels in cerulein-treated mice but inhibited serum response factor synthesis and Smad3 phosphorylation.
Neg (not) Regulation (affect) of TGFbeta
17) Confidence 0.06 Published 2009 Journal Pancreas Section Body Doc Link 19188864 Disease Relevance 0.07 Pain Relevance 0
A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro.
Regulation (affecting) of latency-associated peptide in osteoclast associated with camurati-engelmann disease
18) Confidence 0.05 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12843182 Disease Relevance 0.84 Pain Relevance 0.09
Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells.
Regulation (regulated) of Transforming growth factor in skeletal muscle cells
19) Confidence 0.04 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16682418 Disease Relevance 0.09 Pain Relevance 0.08
namely, the value of the LEP latency is smaller.
Regulation (value) of latency
20) Confidence 0.04 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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