INT12084

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 10
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 20.32
Pain Relevance 12.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
fibroblasts 8
monocytes 5
astrocytes 2
corneal epithelial cells 2
central nervous system 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 310 100.00 Very High Very High Very High
cytokine 200 100.00 Very High Very High Very High
dexamethasone 80 100.00 Very High Very High Very High
Neurotransmitter 16 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
rheumatoid arthritis 174 99.96 Very High Very High Very High
Morphine 16 99.82 Very High Very High Very High
Opioid 5 99.74 Very High Very High Very High
cINOD 52 99.30 Very High Very High Very High
Osteoarthritis 106 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 400 100.00 Very High Very High Very High
Cancer 259 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 44 100.00 Very High Very High Very High
Alzheimer's Dementia 28 100.00 Very High Very High Very High
Rheumatoid Arthritis 181 99.96 Very High Very High Very High
Necrosis 32 99.56 Very High Very High Very High
Anaplastic Astrocytoma 7 99.38 Very High Very High Very High
Osteoarthritis 16 99.06 Very High Very High Very High
Apoptosis 43 96.96 Very High Very High Very High
Hypersensitivity 7 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol (0.01-1000 microM), an unusual analgesic/antipyretic drug which acts preferentially by reducing prostaglandin production within the central nervous system, and indomethacin (0.001-10 microM) caused a clear dose-dependent reduction of prostaglandin E2 production by stimulated T98G cells whereas interleukin-6 release was not affected.
Neg (not) Regulation (affected) of Localization (release) of interleukin-6 in central nervous system associated with paracetamol, analgesic and central nervous system
1) Confidence 0.61 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845273 Disease Relevance 0.64 Pain Relevance 0.56
Morphine (1 pM and 10 nM) alone did not significantly modulate the release of TGF-beta, IL-6 or TNF-alpha.
Neg (not) Regulation (modulate) of Localization (release) of IL-6 associated with morphine
2) Confidence 0.47 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.19 Pain Relevance 0.69
Morphine did not alter the release of immunodetectable IL-6 or TNF-alpha from stimulated cells.
Neg (not) Regulation (alter) of Localization (release) of IL-6 associated with morphine
3) Confidence 0.47 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625199 Disease Relevance 0.16 Pain Relevance 0.82
Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.
Regulation (effect) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma and dexamethasone
4) Confidence 0.44 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.51 Pain Relevance 0.21
The aim of the present study was to investigate if choice of anaesthesia, based on high-dose opioids (fentanyl) versus low-dose opioids influenced the release of IL-6, IL-8, and IL-10.
Regulation (influenced) of Localization (release) of IL-6 associated with opioid
5) Confidence 0.32 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.32 Pain Relevance 0.65
B sequence on the IL-6 promoter is important for HTLV-I-induced IL-6 secretion in cultured synoviocytes [30].
Regulation (important) of Localization (secretion) of IL-6
6) Confidence 0.29 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.63 Pain Relevance 0.27
B sequence on the IL-6 promoter is important for HTLV-I-induced IL-6 secretion in cultured synoviocytes [30].
Regulation (important) of Localization (secretion) of IL-6
7) Confidence 0.29 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.64 Pain Relevance 0.27
In patients with OA or RA, this electrically induced reduction of IL-6 secretion was not significantly changed by alpha- or beta-adrenergic antagonists.
Neg (not) Regulation (changed) of Localization (secretion) of IL-6 associated with antagonist, rheumatoid arthritis and osteoarthritis
8) Confidence 0.27 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415620 Disease Relevance 0.90 Pain Relevance 0.70
Incubation with PGF(2alpha) or the thromboxane A(2) analogue, U46619, had no effect on IL-6 secretion under these conditions.
Neg (no) Regulation (effect) of Localization (secretion) of IL-6
9) Confidence 0.27 Published 2004 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15051033 Disease Relevance 0.13 Pain Relevance 0
Although the effects of individual agents did not vary with the presence or absence of labor, modulation of IL-6 secretion by labor became apparent when agents were combined.


Regulation (modulation) of Localization (secretion) of IL-6
10) Confidence 0.27 Published 2004 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15051033 Disease Relevance 0 Pain Relevance 0
The regulation of interleukin-6 secretion by prostanoids and members of the tumor necrosis factor superfamily in fresh villous fragments of term human placenta.
Regulation (regulation) of Localization (secretion) of interleukin-6 in placenta associated with necrosis and cancer
11) Confidence 0.27 Published 2004 Journal J. Soc. Gynecol. Investig. Section Title Doc Link 15051033 Disease Relevance 0.29 Pain Relevance 0.19
OBJECTIVE: To determine whether prostanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and members of the tumor necrosis factor superfamily can regulate placental secretion of interleukin-6 (IL-6) and whether labor influences any such effects.
Regulation (regulate) of Localization (secretion) of IL-6 associated with necrosis, inflammation, cancer and cinod
12) Confidence 0.27 Published 2004 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15051033 Disease Relevance 0.45 Pain Relevance 0.20
CONCLUSION: Prostanoids, NSAIDs, and the Fas ligand regulate placental IL-6 secretion.
Regulation (regulate) of Localization (secretion) of IL-6
13) Confidence 0.27 Published 2004 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15051033 Disease Relevance 0 Pain Relevance 0
To assess the effects of WIN treatment of PSC on the secretion of cytokines IL-6, MCP-1 and TGFbeta, cell culture supernatants were subjected to ELISA.
Regulation (effects) of Localization (secretion) of IL-6 associated with primary sclerosing cholangitis and cytokine
14) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.63 Pain Relevance 0.34
In one study ET-1 transiently increased IL-6 mRNA compatible with regulation of IL-6 release at the pretranslational level.
Regulation (regulation) of Localization (release) of IL-6
15) Confidence 0.23 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.57 Pain Relevance 0.14
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Regulation (effect) of Localization (release) of IL-6 associated with inflammation
16) Confidence 0.23 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.62 Pain Relevance 0.21
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Regulation (anti) of Localization (release) of IL-6 associated with inflammation
17) Confidence 0.23 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.62 Pain Relevance 0.21
RA is a chronic inflammatory disease defined by articular inflammation which results in joint destruction.1 RA is thought to begin when the immune system acquires immunity to an unknown self antigen, and this anti-self immune response later diversifies and evolves into a chronic inflammatory process.12 This dysregulation of the immune system is evidenced by the presence of autoantibodies such as anti-cyclic citrullinated peptide and rheumatoid factor, both of which are present many years prior to the patient presenting with clinical symptoms.13,14 The pathogenesis of rheumatoid arthritis (RA) involves the release of pro-inflammatory mediators, including IL-6, from infiltrating lymphocytes and monocytes in the synovium.
Regulation (involves) of Localization (release) of IL-6 in monocytes associated with inflammatory mediators, inflammation, rheumatoid arthritis and disease
18) Confidence 0.22 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 1.70 Pain Relevance 0.79
Modulation of spontaneous secretion of IL-6 and IL-8 was investigated in vitro using the neurotransmitters noted above.
Regulation (Modulation) of Localization (secretion) of IL-6
19) Confidence 0.21 Published 2000 Journal J. Rheumatol. Section Body Doc Link 11093434 Disease Relevance 0.28 Pain Relevance 0
We studied the influence of these neurotransmitters on secretion of interleukin 6 (IL-6) and IL-8 in primary cultures of synovial fibroblasts of patients with rheumatoid arthritis (RA) compared to osteoarthritis (OA).
Regulation (influence) of Localization (secretion) of IL-6 in fibroblasts associated with neurotransmitter, rheumatoid arthritis and osteoarthritis
20) Confidence 0.21 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 11093434 Disease Relevance 0.53 Pain Relevance 0.58

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